ArticleScientific reports2020
Dynamic Effects of Aortic Arch Stiffening on Pulsatile Energy Transmission to Cerebral Vasculature as A Determinant of Brain-Heart Coupling.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The Carotid Siphon as a Pulsatility Modulator for Brain Protection: Role of Arterial Calcification Formation.Journal of personalized medicine · 2025Review
- Aortic stretch and recoil create wave-pumping effect: the second heart in the systemic circulation.Journal of the Royal Society, Interface · 2025Article
- Development of a High-Fidelity Benchtop Model for Simultaneous Flow, Pressure, and Imaging Assessment of Transarterial Embolization Procedures.Cardiovascular engineering and technology · 2024Article
- Measuring global cerebrovascular pulsatility transmission using 4D flow MRI.Scientific reports · 2024Article
- Assessing pressure wave components for aortic stiffness monitoring through spectral regression learning.European heart journal open · 2024Article
- Article
- Article
- Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system.American journal of physiology. Heart and circulatory physiology · 2023Article
- On the Longitudinal Wave Pumping in Fluid-filled Compliant Tubes.Physics of fluids (Woodbury, N.Y. : 1994) · 2023Article
- Non-Invasive Pressure-Only Aortic Wave Intensity Evaluation Using Hybrid Fourier Decomposition-Machine Learning Approach.IEEE transactions on bio-medical engineering · 2023Article
- The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion.Frontiers in physiology · 2023Article
- The Relationship of Vascular Aging to Reduced Cognitive Function: Pulsatile and Steady State Arterial Hemodynamics.Pulse (Basel, Switzerland) · 2022Review
- Small Vessel Disease, a Marker of Brain Health: What the Radiologist Needs to Know.AJNR. American journal of neuroradiology · 2022Review
- The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.Frontiers in cardiovascular medicine · 2022Article
- Article
- Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection.Frontiers in bioengineering and biotechnology · 2022Article
- Effectiveness of pulsatility index of carotid Doppler ultrasonography to predict cardiovascular events.Journal of medical ultrasonics (2001) · 2022Article
- Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow.Cell death discovery · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aortic stiffness increases with age and is a robust predictor of brain pathology including Alzheimer's and other dementias. Aging causes disproportionate stiffening of the aorta compared with the carotid arteries, reducing protective impedance mismatches at their interface and affecting transmission of destructive pulsatile energy to the cerebral circulation. Recent clinical studies have measured regional stiffness within the aortic arch using pulse wave velocity (PWV) and have found a stronger association with cerebrovascular events than global stiffness measures. However, effects of aortic arch PWV on the transmission of harmful excessive pulsatile energy to the brain is not well-understood. In this study, we use an energy-based analysis of hemodynamic waves to quantify the effect of aortic arch stiffening on transmitted pulsatility to cerebral vasculature, employing a computational approach using a one-dimensional model of the human vascular network. Results show there exists an optimum wave condition-occurring near normal human heart rates-that minimizes pulsatile energy transmission to the brain. This indicates the important role of aortic arch biomechanics on heart-brain coupling. Our results also suggest that energy-based indices of pulsatility combining pressure and flow data are more sensitive to increased stiffness than using flow or pressure pulsatility indices in isolation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.