ArticleNature communications2020
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
- An update on regulation of the polymodal TRPV4 channel by protein phosphorylation.Channels (Austin, Tex.) · 2026Review
- An ROS-responsive, RGC-targeted nanotherapeutic strategy with a TRPV4 antagonist restores autophagic flux and protects RGCs in a rat model of chronic ocular hypertension.Journal of nanobiotechnology · 2026Article
- Microglial Lyn Kinase-TRPV4 axis mediates social deficits in a maternal immune activation model.Journal of neuroinflammation · 2026Article
- The Broad Clinical Spectrum of Metatropic Dysplasia: A Case Series and Literature Review.International journal of molecular sciences · 2025Review
- Blocking axon-glial mechanotransduction to prevent concussive brain injury.Acta neuropathologica communications · 2025Article
- Mechanosensitive ion channels and inflammation: key links in cellular signal transduction.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Conserved and Unique Mitochondrial Target Sequence of TRPV4 Can Independently Regulate Mitochondrial Functions.Proteins · 2025Article
- TRPV4 Channel in Neurological Disease: from Molecular Mechanisms to Therapeutic Potential.Molecular neurobiology · 2025Review
- Combined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants.Brain : a journal of neurology · 2025Article
- TRPV4 neuromuscular disease registry highlights bulbar, skeletal and proximal limb manifestations.Brain : a journal of neurology · 2025Article
- GluN2B influences the progression of status epilepticus by modulating calcium ion homeostasis through its interaction with CaMKIIα.Frontiers in pharmacology · 2025Article
- Tuina Alleviates Neuropathic Pain in CCI Rats by Regulating the TRPV4-CaMKII Signaling Pathway in Dorsal Root Ganglion.Pain research & management · 2025Article
- Clinical and Genetic Profiles of 5q- and Non-5q-Spinal Muscular Atrophy Diseases in Pediatric Patients.Genes · 2024Review
- Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Intermittent Hypoxic Preconditioning Plays a Cardioprotective Role in Doxorubicin-Induced Cardiomyopathy.Cardiovascular toxicology · 2023Article
- Disruption of axonal transport in neurodegeneration.The Journal of clinical investigation · 2023Review
- Early onset hereditary neuronopathies: an update on non-5q motor neuron diseases.Brain : a journal of neurology · 2023Review
- Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.Frontiers in molecular neuroscience · 2023Article
- Sleep need-dependent changes in functional connectivity facilitate transmission of homeostatic sleep drive.Current biology : CB · 2022Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 2 institutions in 1 country.
Brian M WoolumsDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brett A McCrayDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hyun SungDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Masashi TabuchiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8734-6922
Jeremy M SullivanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kendra Takle RuppellNeurobiology Department, UMass Medical School, Worcester, MA, USA.
Yunpeng YangDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Catherine MamahDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
William H AisenbergDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pamela C Saavedra-RiveraDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bryan S LarinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander R LauDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Douglas N RobinsonDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yang XiangNeurobiology Department, UMass Medical School, Worcester, MA, USA.
Mark N WuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charlotte J SumnerDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. csumner1@jhmi.edu.ORCID http://orcid.org/0000-0001-5088-6012
Thomas E LloydDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. tlloyd4@jhmi.edu.ORCID http://orcid.org/0000-0003-4756-3700
Johns Hopkins University · USUniversity of Massachusetts Chan Medical School · US
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MMurine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9MThe Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3MTraining Program In Cellular and Molecular MedicineT32GM135457 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAJINI RAO · 2020 to 2026
$5.4MNucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4MDynactin function in axons, synapses, and neurodegenerative diseaseR01NS082563 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E. · 2013 to 2017
$1.8MMuscle and neuromuscular junctions in spinal muscular atrophyR01NS062869 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUMNER, CHARLOTTE JANE · 2009 to 2013
$1.7MPathogenesis of TRPV4-related peripheral neuropathyK08NS102509 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCRAY, BRETT ANDREW · 2018 to 2022
$997kExploring disruption of ubiquitination as a mechanism of TRPV4 gain-of-channel function in CMT2CF31NS105404 · NINDS · JOHNS HOPKINS UNIVERSITY · PI AISENBERG, WILLIAM · 2018 to 2019
$90kNIGMS NIH HHS R01 GM066817NIGMS NIH HHS T32 GM135457NIH HHS P40 OD018537NINDS NIH HHS F31 NS105404NINDS NIH HHS K08 NS102509NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS062869NINDS NIH HHS R01 NS082563NINDS NIH HHS R01 NS094239
Abstract
The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here, we show that in vivo expression of a neuropathy-causing TRPV4 mutant (TRPV4
Indexed as
AnimalsAnimals, Genetically ModifiedAxonsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCells, CulturedDrosophila melanogasterHumansMiceMice, Inbred C57BLMitochondriaNeurodegenerative DiseasesTRPV Cation ChannelsWings, AnimalCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2TRPV4 protein, humanTRPV Cation Channels
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.