ArticleScientific reports2020
Development and selection of low-level multi-drug resistance over an extended range of sub-inhibitory ciprofloxacin concentrations in Escherichia coli.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incorporating a Screening-Level Risk Quotient (RQ_screen) for Assessing Human Health Risk of Pharmaceutical Residues in Consumption Water.International journal of environmental research and public health · 2026Pooled it
- Harnessing the Antimicrobial Potential of Baicalein-Coated FeACS applied materials & interfaces · 2026Article
- Fosfomycin at sub-minimum inhibitory concentration impairs biofilm and efflux pump activity in multidrug-resistant Klebsiella pneumoniae isolates.BMC microbiology · 2026Article
- Proteome-wide remodelling in Klebsiella pneumoniae during step-wise adaptive evolution against colistin.PloS one · 2026Article
- Induction of colistin resistance and environmental toxicity assessment in Escherichia coli.PloS one · 2026Article
- Association between farm-level antimicrobial usage and antimicrobial resistance in Escherichia coli isolates from healthy swine in ten farms in Japan.The Journal of veterinary medical science · 2025Article
- The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli.npj antimicrobials and resistance · 2025Article
- Deciphering Common Genetic Pathways to Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2025Article
- The diverse phenotypic and mutational landscape induced by fluoroquinolone treatment.mSystems · 2025Article
- Knowledge and Misconceptions About Antibiotic Use and Resistance Among Dental Clinic Visitors in Saudi Arabia-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Impact of clinical preparation steps and use of sex-specific reference for accurate antibiotic monitoring in body fluids.Communications medicine · 2025Article
- Laboratory evolution ofJournal of bacteriology · 2025Article
- Insights into antibiotic resistance promoted by quinolone exposure.Antimicrobial agents and chemotherapy · 2025Article
- Environmental concentrations of copper and iron can alter the evolution of antimicrobial resistance ofFrontiers in microbiology · 2025Article
- Limited integration of one health and antimicrobial resistance within biodiversity strategies.Discover public health · 2025Review
- The SOS Response Activation and the Risk of Antibiotic Resistance Enhancement inInternational journal of molecular sciences · 2024Article
- Article
- Characterization of antibiotic resistance development ofbioRxiv : the preprint server for biology · 2024Article
- Effect of biofilm physical characteristics on their susceptibility to antibiotics: impacts of low-frequency ultrasound.NPJ biofilms and microbiomes · 2024Article
- Laboratory evolution ofbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To better combat bacterial antibiotic resistance, a growing global health threat, it is imperative to understand its drivers and underlying biological mechanisms. One potential driver of antibiotic resistance is exposure to sub-inhibitory concentrations of antibiotics. This occurs in both the environment and clinic, from agricultural contamination to incorrect dosing and usage of poor-quality medicines. To better understand this driver, we tested the effect of a broad range of ciprofloxacin concentrations on antibiotic resistance development in Escherichia coli. We observed the emergence of stable, low-level multi-drug resistance that was both time and concentration dependent. Furthermore, we identified a spectrum of single mutations in strains with resistant phenotypes, both previously described and novel. Low-level class-wide resistance, which often goes undetected in the clinic, may allow for bacterial survival and establishment of a reservoir for outbreaks of high-level antibiotic resistant infections.
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