Trial report in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.0field-weighted citation impact, top 61% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
International journal of molecular sciences · 2020
Review
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 3 institutions in 3 countries.
Angelino T TrompDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0003-3067-1940
Yuxi ZhaoDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0002-4440-8257
Ilse JongeriusDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0002-7759-9897
Erik C J M HeeziusDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Pauline AbrialCentre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France.
Maartje RuykenDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Jos A G van StrijpDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0001-6253-0830
Carla J C de HaasDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0002-1127-095X
András N SpaanDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Kok P M van KesselDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Thomas HenrySanquin Research, Department of Immunopathology, 1006AD Amsterdam, The Netherlands.ORCID 0000-0002-0687-8565
Pieter-Jan A HaasDepartment of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands P.J.A.Haas@umcutrecht.nl.ORCID 0000-0002-1127-095X
University Medical Center Utrecht · NLSanquin · NLUniversité Claude Bernard Lyon 1 · FR
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Bacterial pathogens have evolved to secrete strong anti-inflammatory proteins that target the immune system. It was long speculated whether these virulence factors could serve as therapeutics in diseases in which abnormal immune activation plays a role. We adopted the secreted chemotaxis inhibitory protein of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein. · full record | OpenQuestion