Evidence map›Paper›PMID 32471890›Full record

ArticleJournal of clinical pathology2021

Clinical implementation of circulating tumour DNA testing for

Tara Spence, Sheron Perera, Jessica Weiss, Sylvie Grenier, Laura Ranich, Frances Shepherd, Tracy L Stockley

Abstract read
In one paragraph

Article in Journal of clinical pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Journal of thoracic disease · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. A Pan-Canadian Validation Study for the Detection ofJTO clinical and research reports · 2021
    Article
  13. Review
  14. Article
  15. Dynamic cfDNA Analysis by NGS inFrontiers in oncology · 2021
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tara SpenceDivision of Clinical Laboratory Genetics, University Health Network, Toronto, Ontario, Canada.
Sheron PereraDepartment of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Jessica WeissDepartment of Biostatistics, University Health Network, Toronto, Ontario, Canada.
Sylvie GrenierDivision of Clinical Laboratory Genetics, University Health Network, Toronto, Ontario, Canada.
Laura RanichDivision of Clinical Laboratory Genetics, University Health Network, Toronto, Ontario, Canada.
Frances ShepherdDepartment of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Tracy L StockleyDivision of Clinical Laboratory Genetics, University Health Network, Toronto, Ontario, Canada Tracy.stockley@uhn.ca.ORCID http://orcid.org/0000-0002-4476-9722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsEpidermal growth factor receptor (

methodsUsing droplet digital PCR (ddPCR), we examined the

resultsOf the 343 patients with liquid biopsy test results, 24% were T790M positive. No clear clinical correlation with a T790M positive test result was identified in this study, although the number of metastatic sites did correlate significantly with the presence of

conclusionsThe ddPCR test for

Indexed as

AcrylamidesAdultAgedAniline CompoundsAntineoplastic AgentsCarcinoma, Non-Small-Cell LungCirculating Tumor DNADrug Resistance, NeoplasmErbB ReceptorsFemaleHumansIndolesLiquid BiopsyLung NeoplasmsMaleMiddle AgedAcrylamidesAniline CompoundsAntineoplastic AgentsCirculating Tumor DNAEGFR protein, humanErbB ReceptorsIndolesosimertinibPyrimidinesbiomarkers, tumorcarcinomalung neoplasms

Identifiers

PMID32471890
PMCPMC7841482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.