ArticleeNeuro
Functional Connectome Analyses Reveal the Human Olfactory Network Organization.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Olfaction and Executive Cognitive Performance: A Systematic Review.Frontiers in psychology · 2022Pooled it
- A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia.Brain structure & function · 2022Pooled it
- Anchoring the human olfactory system within a functional gradient.NeuroImage · 2020Pooled it
- Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population-Based Rhineland Study.International forum of allergy & rhinology · 2026Article
- Stimulating and Recording Brain Signals in an Olfactory Context: Non-Canonical Brain Structures May Contribute to Olfactory Processing - A Case Series.Brain topography · 2026Article
- Olfactory network reorganization in Parkinson's disease.Parkinsonism & related disorders · 2025Article
- Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Dogs' olfactory resting-state functional connectivity is modulated by age and brain shape.Scientific reports · 2025Article
- Identifying the human olfactory and chemosignaling neural networks using event related fMRI and graph theory.Scientific reports · 2025Article
- Olfactory Network Disruptions as Mediators of Cognitive Impairment in De Novo Parkinson's Disease.CNS neuroscience & therapeutics · 2025Article
- Infections withFrontiers in aging neuroscience · 2025Review
- Long-lasting effects of lavender exposure on brain resting-state networks in healthy women.Frontiers in neuroscience · 2025Article
- Characteristics of subjective olfactory dysfunction and imaging features in patients with traumatic olfactory disorders: a retrospective case-control study.Quantitative imaging in medicine and surgery · 2024Article
- Threat Memory in the Sensory Cortex: Insights from Olfaction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The effect of the apolipoprotein E ε4 allele and olfactory function on odor identification networks.Brain and behavior · 2024Article
- Semantic context-dependent neural representations of odors in the human piriform cortex revealed by 7T MRI.Human brain mapping · 2024Article
- The involvement of the piriform cortex in non-lesional temporal lobe epilepsy: an uncommon component of the epileptogenic network.Brain communications · 2024Article
- Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum.Frontiers in neuroscience · 2024Review
- fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.Frontiers in neuroscience · 2024Review
- Remote effects of temporal lobe epilepsy surgery: Long-term morphological changes after surgical resection.Epilepsia open · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The olfactory system is uniquely heterogeneous, performing multifaceted functions (beyond basic sensory processing) across diverse, widely distributed neural substrates. While knowledge of human olfaction continues to grow, it remains unclear how the olfactory network is organized to serve this unique set of functions. Leveraging a large and high-quality resting-state functional magnetic resonance imaging (rs-fMRI) dataset of nearly 900 participants from the Human Connectome Project (HCP), we identified a human olfactory network encompassing cortical and subcortical regions across the temporal and frontal lobes. Highlighting its reliability and generalizability, the connectivity matrix of this olfactory network mapped closely onto that extracted from an independent rs-fMRI dataset. Graph theoretical analysis further explicated the organizational principles of the network. The olfactory network exhibits a modular composition of three (i.e., the sensory, limbic, and frontal) subnetworks and demonstrates strong small-world properties, high in both global integration and local segregation (i.e., circuit specialization). This network organization thus ensures the segregation of local circuits, which are nonetheless integrated via connecting hubs [i.e., amygdala (AMY) and anterior insula (INSa)], thereby enabling the specialized, yet integrative, functions of olfaction. In particular, the degree of local segregation positively predicted olfactory discrimination performance in the independent sample, which we infer as a functional advantage of the network organization. In sum, an olfactory functional network has been identified through the large HCP dataset, affording a representative template of the human olfactory functional neuroanatomy. Importantly, the topological analysis of the olfactory network provides network-level insights into the remarkable functional specialization and spatial segregation of the olfactory system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.