ArticleDevelopment (Cambridge, England)2020
Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse.
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Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
2.4field-weighted citation impact, top 8% of its field
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Epigenetic, environmental, and sex-specific programming of long-term health in Assisted Reproductive Technologies-conceived offspring†.Biology of reproduction · 2026Review
- Ultra-low oxygen tension duringbioRxiv : the preprint server for biology · 2026Article
- Once, twice, three times frozen: viability and post-transfer outcomes of fresh and vitrified-warmed mouse embryos.Human reproduction (Oxford, England) · 2026Article
- Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.Biology of reproduction · 2026Article
- Reappraisal of adverse obstetric outcomes independently associated with contemporary fertility treatment practices: a US prospective cohort study.American journal of obstetrics and gynecology · 2026Article
- The impact of melatonin-enriched media on epigenetic and perinatal changes induced by embryo culture in a mouse model.Journal of assisted reproduction and genetics · 2025Article
- In Vitro Fertilization Accelerates Female Reproductive Aging Through Early Ovarian Failure.bioRxiv : the preprint server for biology · 2025Article
- Impact of embryo culture and day of embryo transfer on the cardiometabolic health of adult mice†.Biology of reproduction · 2025Article
- The Absence of Bovine Serum Albumin (BSA) in Preimplantation Culture Media Impairs Embryonic Development and Induces Metabolic Alterations in Mouse Offspring.International journal of molecular sciences · 2025Article
- In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects.JCI insight · 2025Article
- Chloroquine mitigates long-term effects of in vitro culture in mouse embryos.Frontiers in cell and developmental biology · 2025Article
- Trophectoderm biopsy of blastocysts following IVF and embryo culture increases epigenetic dysregulation in a mouse model.Human reproduction (Oxford, England) · 2024Article
- Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations.Human molecular genetics · 2023Article
- Increased Risk of Preeclampsia with Assisted Reproductive Technologies.Current hypertension reports · 2023Review
- Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation.Human reproduction (Oxford, England) · 2023Article
- Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model.Molecular human reproduction · 2023Article
- Assisted Reproductive Technology without Embryo Discarding or Freezing in Women ≥40 Years: A 5-Year Retrospective Study at a Single Center in Italy.Journal of clinical medicine · 2023Article
- DysregulatedeLife · 2022Article
- Embryo cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas.Human molecular genetics · 2022Article
- Sex differences in the intergenerational inheritance of metabolic traits.Nature metabolism · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Lisa A VroomanEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2202-1051
Eric A Rhon-CalderonEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8128-724X
Olivia Y ChaoEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Duy K NguyenEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2312-2567
Laren NarapareddyEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3327-4089
Asha K DahiyaEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mary E PuttDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7954-1288
Richard M SchultzDepartment of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5923-6825
Marisa S BartolomeiEpigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA bartolom@pennmedicine.upenn.edu.ORCID 0000-0001-9410-5222
Epigénétique et Destin Cellulaire · FRUniversity of Pennsylvania · US
Funding
Research Project 4: Epigenetic Regulation of Retrotransposon Silencing and Male Fertility in the MouseP50HD068157 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI MARISA S. BARTOLOMEI · 2014 to 2026
$16.3MRESEARCH ON VULNERABLE WOMEN CHILDREN AND FAMILIEST32NR007100 · NINR · UNIVERSITY OF PENNSYLVANIA · PI MEDOFF-COOPER, BARBARA S · 1998 to 2018
$7.2MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3MPROJECT 4: TARGETING ADP-RIBOSE POLYMER DEPENDENT EPIGENETIC EVENTS IN MALE LINEU54HD068157 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BERGER, SHELLEY L · 2011 to 2013
$4.8MLong-term physiological and behavioral outcomes, epigenetic profiles and multigenerational phenotypes in a mouse ART modelR01HD092266 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2017 to 2021
$1.7MInvestigation of epigenetic and morphological placental abnormalities induced by in vitro fertilizationF32HD089623 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI VROOMAN, LISA ANNE · 2017 to 2020
$204kNICHD NIH HHS F32 HD089623NICHD NIH HHS P50 HD068157NICHD NIH HHS U54 HD068157NINR NIH HHS T32 NR007100
Abstract
Although widely used, assisted reproductive technologies (ARTs) are associated with adverse perinatal outcomes. To elucidate their underlying causes, we have conducted a longitudinal analysis of placental development and fetal growth using a mouse model to investigate the effects of individual ART procedures: hormone stimulation,
Indexed as
AnimalsDNA MethylationEmbryo, MammalianEmbryonic DevelopmentEmbryo TransferFemaleFertilization in VitroMaleMiceMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersPlacentaPre-EclampsiaPregnancyRiskSymportersFlt1 protein, mouseMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSlc16a3 protein, mouseSymportersVascular Endothelial Growth Factor Receptor-1Assisted reproductive technologiesFetal growthPlacentaPreeclampsiasFLT1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.