ReviewRadiation oncology (London, England)2020
MR-guided proton therapy: a review and a preview.
Review in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of volumetric image guidance in proton therapy.Physical and engineering sciences in medicine · 2023Pooled it
- Health Economic Evaluation of Proton Therapy for Lung Cancer: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Feasibility of ultra-low-field MRI in an ion beam treatment room for online MR-guided particle therapy.Physics and imaging in radiation oncology · 2026Article
- Development of a GPU-based dose calculation engine for MRI-guided proton therapy.Medical physics · 2026Article
- Deep learning-based generation of direct stopping power ratio maps for MR-only proton therapy of primary brain tumor patients.Physics and imaging in radiation oncology · 2026Article
- Towards a shuttle-based workflow for daily online magnetic resonance imaging-guided particle therapy: Anatomical robustness and organ variability in the female pelvis.Technical innovations & patient support in radiation oncology · 2026Article
- Assessing the quality of deformable image registration in magnetic resonance image guided carbon ion liver radiotherapy with an anthropomorphic phantom.Physics and imaging in radiation oncology · 2026Article
- Comparison of gantry-less magnetic resonance guided proton therapy with photon therapy for hepatocellular carcinoma patients.Physics and imaging in radiation oncology · 2026Article
- Postoperative proton therapy in uterine and cervical cancer: promising evidence but remaining questions.Translational cancer research · 2026Article
- Evaluation of Magnetic Resonance Imaging-Derived Synthetic Computed Tomography in Prostate Cancer Carbon Ion Radiotherapy: Impact of Fixation Shell.International journal of particle therapy · 2026Article
- Dosimetric evaluation of magnetic resonance imaging based synthetic computed tomography for head and neck photon and proton therapy.Journal of applied clinical medical physics · 2025Article
- Cross-modality 3D MRI synthesis via cycle-guided denoising diffusion probability model.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Implications of interfractional bladder volume variations in proton beam therapy for rectal cancer.Radiation oncology journal · 2025Article
- Characterization of a Commercial Ionization Chamber Array With Scanned Proton Beams for Applications in MRI-Guided Proton Therapy.Medical physics · 2025Article
- A proof-of-concept study of direct magnetic resonance imaging-based proton dose calculation for brain tumors via neural networks with Monte Carlo-comparable accuracy.Physics and imaging in radiation oncology · 2025Article
- SynthRAD2025 Grand Challenge dataset: Generating synthetic CTs for radiotherapy from head to abdomen.Medical physics · 2025Article
- Stability of liver position in a shuttle-based workflow for daily online magnetic resonance imaging-guided particle therapy.Physics and imaging in radiation oncology · 2025Article
- Diffusion Schrödinger bridge models for high-quality MR-to-CT synthesis for proton treatment planning.Medical physics · 2025Article
- MR imaging of proton beam-induced oxygen depletion.Medical physics · 2025Article
- Ultra-low field magnetic resonance breast imaging in prone and seated positions for radiation therapy.Physics and imaging in radiation oncology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundThe targeting accuracy of proton therapy (PT) for moving soft-tissue tumours is expected to greatly improve by real-time magnetic resonance imaging (MRI) guidance. The integration of MRI and PT at the treatment isocenter would offer the opportunity of combining the unparalleled soft-tissue contrast and real-time imaging capabilities of MRI with the most conformal dose distribution and best dose steering capability provided by modern PT. However, hybrid systems for MR-integrated PT (MRiPT) have not been realized so far due to a number of hitherto open technological challenges. In recent years, various research groups have started addressing these challenges and exploring the technical feasibility and clinical potential of MRiPT. The aim of this contribution is to review the different aspects of MRiPT, to report on the status quo and to identify important future research topics.
methodsFour aspects currently under study and their future directions are discussed: modelling and experimental investigations of electromagnetic interactions between the MRI and PT systems, integration of MRiPT workflows in clinical facilities, proton dose calculation algorithms in magnetic fields, and MRI-only based proton treatment planning approaches.
conclusionsAlthough MRiPT is still in its infancy, significant progress on all four aspects has been made, showing promising results that justify further efforts for research and development to be undertaken. First non-clinical research solutions have recently been realized and are being thoroughly characterized. The prospect that first prototype MRiPT systems for clinical use will likely exist within the next 5 to 10 years seems realistic, but requires significant work to be performed by collaborative efforts of research groups and industrial partners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.