Evidence map›Paper›PMID 32471473›Full record

SynthesisBMC neurology2020

Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis.

Mina Mohammadhosayni, Arezou Khosrojerdi, Keivan Lorian, Saeed Aslani, Danyal Imani, Bahman Razi, Farhad Babaie, Shahram Torkamandi

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Role of fenofibrate in multiple sclerosis.European journal of medical research · 2024
    Review
  6. Review
  7. Article
  8. 1,25(OH)International journal of molecular sciences · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mina MohammadhosayniDepartment of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran.
Arezou KhosrojerdiDepartment of Medical Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Keivan LorianDepartment of Physiology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Saeed AslaniDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Danyal ImaniDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Bahman RaziDepartment of Hematology and Blood Transfusion, School of Medicine, Tarbiat Modares University, Tehran, Iran.
Farhad BabaieCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Shahram TorkamandiDepartment of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Torkmandishahram1370@gmail.com.
Tehran University of Medical Sciences · IRTarbiat Modares University · IRShahed University · IRUrmia University · IRUrmia University of Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). However, the results have been inconsistent and inconclusive. To resolve this issue, here we performed a systematic review and meta-analysis of the MMP-91562 C/T (rs3918242), MMP-3 (- 1612 5A/6A), and MMP-2 (- 1306 C/T) polymorphisms and susceptibility to MS.

methodsWe conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies published before December 2019 that surveyed the association between the MMP-91562 C/T (rs3918242), MMP-3 (- 1612 5A/6A), and MMP-2 (- 1306 C/T) polymorphisms and susceptibility to MS. The level of association between the polymorphisms and susceptibility to MS in the polled analysis was determined by calculating the odds ratio (OR) and the corresponding 95% confidence interval (CI).

resultsWe found 15 studies containing 2430 MS subjects and 2304 controls. A statistically significant association was observed in the all five comparisons of the MMP-91562 C/T polymorphism and MS risk as follows: dominant model (OR = 1.62, 95% CI = 1.03-2.53, P = 0.03), recessive model (OR = 2.69, 95% CI = 1.68-4.29, P < 0.001), allelic model (OR = 1.51, 95% CI = 1-2.28, P = 0.04), TT vs. CC model (OR = 3.20, 95% CI = 1.87-5.46, P < 0.001), and CT vs. CC model (OR = 1.53, 95% CI = 1.02-2.28, P = 0.04).

conclusionsOur meta-analysis revealed significant association of MMP-9 (- 1562 C/T) Single-nucleotide polymorphism (SNP) with MS susceptibility that increased the disease risk.

Indexed as

Genetic Predisposition to DiseaseHumansMaleMatrix Metalloproteinase 9Matrix MetalloproteinasesMultiple SclerosisOdds RatioPolymorphism, Single NucleotideMatrix Metalloproteinase 9Matrix MetalloproteinasesMMP9 protein, humanCentral nervous systemGenetic polymorphismMatrix metalloproteinasesMeta-analysisMultiple sclerosis

Identifiers

PMID32471473
PMCPMC7257507
OpenAlexW3031088187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.