ArticleThe journal of headache and pain2020
The impact of remission and coexisting migraine on anxiety and depression in cluster headache.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical Characteristics and Patient Burden of Cluster Headache in Brazil: A Real-World Study.Advances in therapy · 2026Article
- Sex differences in cluster headache: insights from the Chinese Cluster Headache Register Individual Study (CHRIS).The journal of headache and pain · 2026Observational
- Association Between the Frailty Index and Self-Reported Headache in Middle-Aged and Older Chinese Adults: An Analysis of the China Health and Retirement Longitudinal Study.Pain research & management · 2026Article
- Inverse association of obesity with bout periodicity in episodic cluster headache: a multicenter cross-sectional study.The journal of headache and pain · 2025Observational
- Association of Dexmedetomidine With Postoperative Depressive Symptoms in Older Surgical Patients: A Prospective Multicenter Study.CNS neuroscience & therapeutics · 2025Observational
- Advancing Antidepressive Agents: Drug Discovery and Polymer-Based Drug Delivery Systems for Improved Treatment Outcome.Biomedicines · 2025Review
- Headache Phenotype and the Psychosocial Burden of Cluster Headaches: An Analysis of Patients Prior to Hospitalization.Pain and therapy · 2025Article
- Unraveling the relationship between inflammation and cluster headache.Frontiers in neurology · 2025Review
- The relation of cluster headache to alexithymia, depression, and anxiety.Arquivos de neuro-psiquiatria · 2024Article
- Urine 5-Hydroxyindoleacetic Acid Negatively Correlates with Migraine Occurrence and Characteristics in the Interictal Phase of Episodic Migraine.International journal of molecular sciences · 2024Article
- Comorbidity of migraine and fibromyalgia in patients with cluster headache: psychological burden and healthcare resource utilization. A cross-sectional study.Journal of oral & facial pain and headache · 2024Article
- An Analysis of the Determinants of the Health-Related Quality of Life in Asian Patients With Cluster Headaches During Cluster Periods Using the Time Trade-Off Method.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Multimorbidity and Sickness Absence/Disability Pension in Patients With Cluster Headache and Matched References: A Swedish Register-Based Study.Neurology · 2023Article
- Therapy for Psychiatric Comorbidities in Patients with Episodic Cluster Headache: A Prospective Multicenter Study.Journal of pain research · 2022Article
- Diagnostic Delay and Its Predictors in Cluster Headache.Frontiers in neurology · 2022Article
- Phenotype of Cluster Headache: Clinical Variability, Persisting Pain Between Attacks, and Comorbidities-An Observational Cohort Study in 825 Patients.Pain and therapy · 2021Article
- Cluster Headache is Still Lurking in the Shadows.Pain and therapy · 2021Article
- Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study.Scientific reports · 2021Article
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Authors and funding
20 authors at 15 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.
methodsWe analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods.
resultsAmong the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35-15.99 and aOR = 4.95, 95% CI = 2.32-10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63-159.64 and aOR = 16.88, 95% CI = 4.16-68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 ± 5.6 to 1.6 ± 2.8; P < 0.001, and from 6.1 ± 5.0 to 1.8 ± 2.4; P < 0.001, respectively).
conclusionsOur results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.
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