Evidence map›Paper›PMID 32471283›Full record

ArticleInsects2020

RNA Interference Is Enhanced by Knockdown of double-stranded RNases in the Yellow Fever Mosquito

David Giesbrecht, Daniel Heschuk, Ian Wiens, David Boguski, Parker LaChance, Steve Whyard

Open access · goldAbstract read
In one paragraph

Article in Insects, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Challenges of Robust RNAi-Mediated Gene Silencing inInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Outlook on RNAi-Based Strategies for ControllingPathogens (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Delivery Methods for RNAi in Mosquito Larvae.Journal of insect science (Online) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David GiesbrechtDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0003-2498-4705
Daniel HeschukDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Ian WiensDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
David BoguskiDepartment of Fisheries and Oceans, Winnipeg, MB R3T 2N2, Canada.
Parker LaChanceDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Steve WhyardDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-9874-7780
University of Manitoba · CAFisheries and Oceans Canada · CA

Funding

National Health and Medical Research Council APP1082127Natural Sciences and Engineering Research Council of Canada 491898
6 · The paper itself

Abstract

RNA interference (RNAi) techniques are being developed for a range of pest insect control technologies, including the sterile insect technique (SIT) and double-stranded RNA (dsRNA)-based insecticides. In SIT applications, where >99% of the released males should be sterile to meet industry standards, the efficiency of RNAi will need to be improved for many insect species if this technology is to be adopted. Endogenous dsRNases can impede dsRNA delivery in some insects, and, here, we investigated whether dsRNases in the midgut could limit RNAi efficacy in the mosquito

Indexed as

AedesdsRNasemosquitoNucleaseRNAi

Identifiers

PMID32471283
PMCPMC7349537
OpenAlexW3030139823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.