Evidence map›Paper›PMID 32471251›Full record

ReviewNutrients2020

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis.

Mohammed Iddir, Alex Brito, Giulia Dingeo, Sofia Sosa Fernandez Del Campo, Hanen Samouda, Michael R La Frano, Torsten Bohn

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06402227 (Effectiveness of Board Game on Improving Knowledge, Attitudes and Behavioral Intentions of Infection Control for Senior Elementary School Students), which is not on this map. Cited by 373 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 8 pooled it
72.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06402227 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of Board Game on Improving Knowledge, Attitudes and Behavioral Intentions of Infection Control for Senior Elementary School Students: a Randomized Controlled Trial

TypeinterventionalSponsorHU, HUEY-LANRan2023 to 2024Enrolled310ConditionsKnowledge of Infection Control, Attitude of Infection Control, Behavioral Intentions of Infection ControlArmsgamified instruction, conventional lesson lecture
3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 8 syntheses or guidelines pooled it, 781 citations in OpenAlex.

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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Mohammed IddirNutrition and Health Research Group, Population Health Department, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.ORCID 0000-0001-8656-8921
Alex BritoNutrition and Health Research Group, Population Health Department, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.
Giulia DingeoIndependent Researcher, Val de Marne, 94999 Paris, France.
Sofia Sosa Fernandez Del CampoNutrition and Health Research Group, Population Health Department, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.
Hanen SamoudaNutrition and Health Research Group, Population Health Department, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.
Michael R La FranoDepartment of Food Science and Nutrition, California Polytechnic State University, 1 Grand Avenue, San Luis Obispo, CA 93407, USA.ORCID 0000-0002-2269-1688
Torsten BohnNutrition and Health Research Group, Population Health Department, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.ORCID 0000-0002-7825-0697
Luxembourg Institute of Health · LUAssociation Clinique et Thérapeutique Infantile du Val de Marne · FRCalifornia Polytechnic State University · USSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement. An optimal immune response depends on an adequate diet and nutrition in order to keep infection at bay. For example, sufficient protein intake is crucial for optimal antibody production. Low micronutrient status, such as of vitamin A or zinc, has been associated with increased infection risk. Frequently, poor nutrient status is associated with inflammation and oxidative stress, which in turn can impact the immune system. Dietary constituents with especially high anti-inflammatory and antioxidant capacity include vitamin C, vitamin E, and phytochemicals such as carotenoids and polyphenols. Several of these can interact with transcription factors such as NF-kB and Nrf-2, related to anti-inflammatory and antioxidant effects, respectively. Vitamin D in particular may perturb viral cellular infection via interacting with cell entry receptors (angiotensin converting enzyme 2), ACE2. Dietary fiber, fermented by the gut microbiota into short-chain fatty acids, has also been shown to produce anti-inflammatory effects. In this review, we highlight the importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis.

Indexed as

Coronavirus InfectionsDietPandemicsPneumonia, ViralAntioxidantsBetacoronavirusCOVID-19HumansImmune SystemInflammationNutrientsNutritional StatusOxidative StressSARS-CoV-2AntioxidantsNutrientscoronaviruscytokinesinfectioninnate immune systemmacronutrientsnuclear factorsnutrientprotein intakereactive oxygen speciestrace elementstranscription factors

Identifiers

PMID32471251
PMCPMC7352291
OpenAlexW3029648091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.