Evidence map›Paper›PMID 32471171›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells.

Maria Lehene, Eva Fischer-Fodor, Florina Scurtu, Niculina D Hădade, Emese Gal, Augustin C Mot, Alina Matei, Radu Silaghi-Dumitrescu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria LeheneDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.
Eva Fischer-FodorTumor Biology Laboratory, Institute of Oncology I. Chiricuta, 400015 Cluj-Napoca, Romania.ORCID 0000-0002-0898-0547
Florina ScurtuMedfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400037 Cluj-Napoca, Romania.
Niculina D HădadeDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.
Emese GalDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.
Augustin C MotDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.ORCID 0000-0002-1679-0487
Alina MateiDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.
Radu Silaghi-DumitrescuDepartment of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania.ORCID 0000-0003-3038-7747
Babeș-Bolyai University · ROIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

Ministerul Educației și Cercetării Științifice PN-III-P4-ID-PCE-2016-0089
6 · The paper itself

Abstract

Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.

Indexed as

albuminantioxidantascorbateCOVID-19erythrocytehemoglobinleukocyte

Identifiers

PMID32471171
PMCPMC7344896
OpenAlexW3029307108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.