SynthesisInternational journal of environmental research and public health2020
Social and Structural Determinants of Household Support for ART Adherence in Low- and Middle-Income Countries: A Systematic Review .
Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Including the Household: Individual, Community and Household Factors Affecting Antiretroviral Therapy Adherence After ART Initiation in Cape Town, South Africa.AIDS and behavior · 2024Trial
- Characterizing HIV drug resistance in cases of vertical transmission in the VESTED randomized antiretroviral treatment trial.Journal of acquired immune deficiency syndromes (1999) · 2024Trial
- Preliminary Impact of Group-Based Interventions on Stigma and the Mental Health of Caregivers of Adolescents Living with HIV in Uganda.AIDS and behavior · 2024Trial
- Stay-at-Home: The Impact of the COVID-19 Lockdown on Household Functioning and ART Adherence for People Living with HIV in Three Sub-districts of Cape Town, South Africa.AIDS and behavior · 2022Trial
- Caregiver-Mediated Adherence and Perceived Health System Factors Associated with Viral Suppression Among Children Receiving Antiretroviral Therapy in Rural South Africa.International journal of environmental research and public health · 2026Article
- Weaving the Net: The Interplay of Micro- and Macrosupport in ART Adherence.AIDS research and treatment · 2026Article
- Developing a Naïve Bayes risk classification machine learning algorithm to predict high viral load in a low-resource setting.PLOS global public health · 2026Article
- Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors.World journal of psychiatry · 2025Review
- Validation of the Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) Scale Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender and Nonbinary Persons: Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- 'Those sessions open[ed] our eyes and our minds': participant acceptability and satisfaction with a gender-focused HIV and substance use risk-reduction intervention on alcohol use, HIV treatment, and sexual behaviour among women in South Africa.Health education research · 2025Article
- Family Social Support Mediates the Relationship Between the COVID-19 Pandemic and Psychosocial well-being in a Cohort of Young South Africans Newly Diagnosed with HIV.AIDS and behavior · 2025Article
- Social determinants of adherence to antiretroviral therapy among adolescents and young people living with HIV: a scoping review.Revista da Escola de Enfermagem da U S P · 2025Article
- Perspectives of health workers on the facilitators and barriers to antiretroviral therapy adherence following intensive adherence counseling in Northern Uganda.Frontiers in health services · 2025Article
- Promoting Antiviral Access and Adherence in the Expansion of Hepatitis B Prevention Programs: Insights From the Democratic Republic of Congo.Journal of the Pediatric Infectious Diseases Society · 2024Article
- 'Not taking medications and taking medication, it was the same thing:' perspectives of antiretroviral therapy among people hospitalised with advanced HIV disease.BMC infectious diseases · 2024Article
- Factors influencing adherence to antiretroviral therapy among young adults in Limpopo province.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
- Social networks and HIV treatment adherence among people with HIV initiating treatment in rural Uganda and peri-urban South Africa.SSM - population health · 2024Article
- A policy brief: improving access and utilization of adolescent sexual and reproductive health services in Southern Ethiopia.Frontiers in public health · 2024Article
- Gender and stigma in antiretroviral treatment adherence in Mozambique: A qualitative study.PLOS global public health · 2024Article
- Effects of the COVID-19 pandemic on late postpartum women living with HIV in Kenya.PLOS global public health · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence to HIV antiretroviral therapy (ART) is a crucial factor in health outcomes for people living with HIV (PLWH). Interventions to support ART adherence are increasingly focused on the household as a source of social support. This review aims to examine the social and structural determinants of support for ART adherence within households and families in low- and middle-income countries (LMICs). The review methodology followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Seven databases were searched for peer-reviewed literature. The terms searched thematically covered (1) ART adherence, (2) household and family and (3) support and care. Thirty-three studies conducted in 15 LMICs were selected and a mixed methods synthesis was undertaken. Social and structural determinants affected the type, quality and amount of support for PLWH of all ages, which affected PLWH's ART adherence. Gender norms affected the type of support that household members give to PLWH. Education moderated household support for ART adherence through literacy and language skills. Cultural context, religious beliefs, and social norms reinforced or undermined household support for ART adherence. Stigma affected disclosure, generated secrecy around giving medication and impeded access to support from the community. Supporting PLWH exacerbated economic hardship for household members. Health system dysfunction negatively impacted trust and communication between household members and health professionals. Intersecting social and structural determinants particularly affected the care given by household members who were older, female, with little education and low socioeconomic status. Household members were able to overcome some of these barriers when they received support themselves. Household interventions to support PLWH's ART adherence should take structural factors into account to have maximum impact.
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