Evidence map›Paper›PMID 32471096›Full record

ArticleViruses2020

Are We Ready for NGS HIV Drug Resistance Testing? The Second "Winnipeg Consensus" Symposium.

Hezhao Ji, Paul Sandstrom, Roger Paredes, P Richard Harrigan, Chanson J Brumme, Santiago Avila Rios, Marc Noguera-Julian, Neil Parkin, Rami Kantor

Abstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
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  8. Portable Nanopore sequencing solution for next-generation HIV drug resistance testing.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2024
    Article
  9. Review
  10. Article
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hezhao JiNational HIV and Retrovirology Laboratories at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Paul SandstromNational HIV and Retrovirology Laboratories at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Roger ParedesIrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, s/n, 08916 Badalona, Catalonia, Spain.
P Richard HarriganDivision of AIDS, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Chanson J BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
Santiago Avila RiosCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City 14080, Mexico.
Marc Noguera-JulianIrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, s/n, 08916 Badalona, Catalonia, Spain.
Neil ParkinData First Consulting Inc., Sebastopol, CA 95472, USA.
Rami KantorDivision of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Addressing HIV drug resistance research gaps in a cohort of perinatally infected Kenyan children and adolescentsR01AI147333 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI, VREEMAN, RACHEL CHRISTINE · 2019 to 2024
$3.9M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR01AI136058 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI · 2018 to 2022
$3.4M
HIV Treatment Failure and Drug Resistance in Western Kenyan ChildrenR01AI120792 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KANTOR, RAMI, VREEMAN, RACHEL CHRISTINE · 2016 to 2019
$2.9M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR37AI136058 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2025 to 2026
$1.5M
HIV Drug Resistance, Monitoring and TransmissionK24AI134359 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2018 to 2026
$1.3M
NIAID NIH HHS K24 AI134359NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI120792NIAID NIH HHS R01 AI147333NIAID NIH HHS R37 AI136058
6 · The paper itself

Abstract

HIV drug resistance is a major global challenge to successful and sustainable antiretroviral therapy. Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays enable more sensitive and quantitative detection of drug-resistance-associated mutations (DRMs) and outperform Sanger sequencing approaches in detecting lower abundance resistance mutations. While NGS is likely to become the new standard for routine HIVDR testing, many technical and knowledge gaps remain to be resolved before its generalized adoption in regular clinical care, public health, and research. Recognizing this, we conceived and launched an international symposium series on NGS HIVDR, to bring together leading experts in the field to address these issues through in-depth discussions and brainstorming. Following the first symposium in 2018 (Winnipeg, MB Canada, 21-22 February, 2018), a second "Winnipeg Consensus" symposium was held in September 2019 in Winnipeg, Canada, and was focused on external quality assurance strategies for NGS HIVDR assays. In this paper, we summarize this second symposium's goals and highlights.

Indexed as

High-Throughput Nucleotide SequencingAnti-HIV AgentsCongresses as TopicDrug Resistance, ViralHIVHIV InfectionsHumansAnti-HIV AgentsHIV drug resistance testingNGSsymposiumWinnipeg Consensus

Identifiers

PMID32471096
PMCPMC7354487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.