ArticleNeurosurgery2020
Presurgical Identification of Patients With Glioblastoma at Risk for Cognitive Impairment at 3-Month Follow-up.
Article in Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of Glioblastoma Resection on Cognitive Function and Affective Symptoms at Three-Month Follow-Up.Brain and behavior · 2026Observational
- Cognitive impact of repeated surgical resections for the management of high-grade glioma.Journal of neuro-oncology · 2025Article
- Impact of High-Grade Glioma Lesion Location on Preoperative Neuropsychological Deficits.Cancers · 2025Article
- Developed a knowledge base of risk factors for postoperative cognitive dysfunction: a retrospective database study.Scientific reports · 2025Article
- Modeling and validation in Parkinson's disease patients with frailty.Frontiers in neuroscience · 2025Article
- Modeling and validation of wearable sensor-based gait parameters in Parkinson's disease patients with cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Predicting Cognitive Functioning for Patients with a High-Grade Glioma: Evaluating Different Representations of Tumor Location in a Common Space.Neuroinformatics · 2024Article
- Cognitive functioning in untreated glioma patients: The limited predictive value of clinical variables.Neuro-oncology · 2024Article
- Baseline neurocognitive dysfunction is ubiquitous in intrinsic brain tumors- results from a large Indian cohort of patients and analysis of factors associated with domain-specific dysfunction.World neurosurgery: X · 2023Article
- Acceptability and feasibility of cognitive assessments with adults with primary brain cancer and brain metastasis: A systematic review.Neuro-oncology practice · 2023Review
- A Prospective Study of Longitudinal Risks of Cognitive Deficit for People Undergoing Glioblastoma Surgery Using a Tablet Computer Cognition Testing Battery: Towards Personalized Understanding of Risks to Cognitive Function.Journal of personalized medicine · 2023Article
- The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.European journal of neurology · 2021Article
- T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas.Frontiers in neurology · 2021Article
- Predicting cognitive function 3 months after surgery in patients with a glioma.Neuro-oncology advancesArticle
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPre- and postoperative cognitive deficits have repeatedly been demonstrated in patients with glioblastoma (GBM).
objectiveTo identify presurgical risk factors that facilitate the identification of GBM patients at risk for postoperative cognitive impairment.
methodsPatients underwent neuropsychological assessment using Central Nervous System Vital Signs 1 d before (T0) and 3 mo after surgery (T3). Patients' standardized scores on 7 cognitive domains were compared to a normative sample using one-sample z tests. Reliable change indices with correction for practice effects were calculated to assess cognitive changes in individual patients over time. Logistic regression models were performed to assess presurgical sociodemographic, clinical, psychological, and cognitive risk factors for postoperative cognitive impairments.
resultsAt T0, 208 patients were assessed, and 136 patients were retested at T3. Patients showed significantly lower performance both prior to and 3 mo after surgery on all cognitive domains compared to healthy controls. Improvements and declines over time occurred respectively in 11% to 32% and 6% to 26% of the GBM patients over the domains. The regression models showed that low preoperative cognitive performance posits a significant risk factor for postoperative cognitive impairment on all domains, and female sex was a risk factor for postoperative impairments in Visual Memory.
conclusionWe demonstrated preoperative cognitive risk factors that enable the identification of GBM patients who are at risk for cognitive impairment 3 mo after surgery. This information can help to inform patients and clinicians at an early stage, and emphasizes the importance of recognizing, assessing, and actively dealing with cognitive functioning in the clinical management of GBM patients.
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