Evidence map›Paper›PMID 32470559›Full record

ArticleJournal of molecular biology2020

Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase.

Jiemin Shen, Gang Wu, Ah-Lim Tsai, Ming Zhou

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 69 citations in OpenAlex.

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  14. Structure and Function of Alkane Monooxygenase (AlkB).Accounts of chemical research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiemin ShenVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Gang WuDivision of Hematology, Internal Medicine, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA.
Ah-Lim TsaiDivision of Hematology, Internal Medicine, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA. Electronic address: Ah-Lim.Tsai@uth.tmc.edu.
Ming ZhouVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: mzhou@bcm.edu.
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2M
Structural mechanism of K channel modulation by cellular redox stateR01HL086392 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHOU, MING · 2006 to 2018
$3.9M
Structure and mechanism of mammalian stearoyl-CoA desaturasesR01DK122784 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TSAI, AH-LIM, ZHOU, MING · 2019 to 2023
$3.2M
Structure and Function of a Phosphorylation Coupled Saccharide TransporterR01GM098878 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHOU, MING · 2011 to 2014
$1.2M
NHLBI NIH HHS R01 HL086392NIDDK NIH HHS R01 DK122784NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM098878
6 · The paper itself

Abstract

Stearoyl-CoA desaturase 1 (SCD1) is a membrane-embedded metalloenzyme that catalyzes the formation of a double bond on a saturated acyl-CoA. SCD1 has a diiron center and its proper function requires an electron transport chain composed of NADH (or NADPH), cytochrome b

Indexed as

AnimalsCatalytic DomainCrystallography, X-RayCytochrome-B(5) ReductaseCytochromes b5HEK293 CellsHumansIronMiceModels, MolecularProtein ConformationProtein DomainsSf9 CellsStearoyl-CoA DesaturaseZincCytochrome-B(5) ReductaseCytochromes b5IronScd1 protein, mouseStearoyl-CoA DesaturaseZincdiiron centerdouble-bond formationelectron transfermembrane enzymeSCD1

Identifiers

PMID32470559
PMCPMC7483794
OpenAlexW3029310112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.