ArticleCell2020
Molecular Choreography of Acute Exercise.
4 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 270 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
270citing papers in PubMed, 7 pooled it
31.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot-study on Multi-level Molecular Profiling of Peak Performance in Endurance Sports
Identifying Markers of Exercise Training in Heart Failure
Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures
Targeting Autophagy in Depression: Fasting, Exercise, Diet
Who cites it
270 citing papers in PubMed, 7 syntheses or guidelines pooled it, 455 citations in OpenAlex.
- Exercise modalities and dosages on glycated haemoglobin and exerkines in type 2 diabetes: a systematic review with pairwise, network, and dose-response meta-analyses.Cardiovascular diabetology · 2026Pooled it
- Multi-omics time-series analysis in microbiome research: a systematic review.Briefings in bioinformatics · 2025Pooled it
- The anti-inflammatory effects of exercise on autoimmune diseases: A 20-year systematic review.Journal of sport and health science · 2024Pooled it
- Elucidating regulatory processes of intense physical activity by multi-omics analysis.Military Medical Research · 2023Pooled it
- Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials.Journal of sport and health science · 2023Pooled it
- Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?Journal of cardiovascular translational research · 2023Pooled it
- Effects of exercise of different intensities on withdrawal symptoms among people with substance use disorder: a systematic review and meta-analysis.Frontiers in physiology · 2023Pooled it
- Prenatal exercise interventions result in subtle changes in the human breast milk metabolome and lipidome 7-14 days postpartum: exploratory analyses of the FitMum randomized controlled trial.International breastfeeding journal · 2026Trial
- The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients.EMBO molecular medicine · 2026Trial
- Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans.Journal of translational medicine · 2026Trial
- Dynamic Metabolic Changes Driven by Exercise Intensity in Acute Swimming.Medicine and science in sports and exercise · 2025Trial
- An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial.Nature medicine · 2025Trial
- Exercise intensity determines circulating levels of Lac-Phe and other exerkines: a randomized crossover trial.Metabolomics : Official journal of the Metabolomic Society · 2025Trial
- Circulatory lipid signature in response to short-term testosterone gel treatment of healthy young females.Scientific reports · 2025Trial
- Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury.Genome medicine · 2025Trial
- Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity.American journal of human biology : the official journal of the Human Biology Council · 2024Trial
- Supplementation with food-derived oligopeptides promotes lipid metabolism in young male cyclists: a randomized controlled crossover trial.Journal of the International Society of Sports Nutrition · 2023Trial
- Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults.Physiological genomics · 2023Trial
- Trial
- Blood metabolic profiling associated with a short-term intensive training period in elite male water polo athletes: an exploratory metabolomics study.Journal of the International Society of Sports Nutrition · 2026Article
210 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 4 institutions in 3 countries.
Kévin ContrepoisDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Si WuDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Kegan J MoneghettiStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia; Stanford Sports Cardiology, Department of Medicine, Stanford University, Stanford, CA, USA.
Daniel HornburgDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Sara AhadiDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ming-Shian TsaiDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ahmed A MetwallyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Eric WeiDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Brittany Lee-McMullenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Jeniffer V QuijadaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Songjie ChenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Jeffrey W ChristleStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Sports Cardiology, Department of Medicine, Stanford University, Stanford, CA, USA.
Mathew EllenbergerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Brunilda BalliuDepartment of Pathology, Stanford University, Stanford, CA, USA.
Shalina TaylorPediatrics Department, Stanford University School of Medicine, Stanford, CA, USA.
Matthew G DurrantDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
David A KnowlesDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA.
Hani ChoudhryDepartment of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Melanie AshlandDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Amir BahmaniDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Brooke EnslenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Myriam AmsallemStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Yukari KobayashiStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Monika AvinaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Dalia PerelmanDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Sophia Miryam Schüssler-Fiorenza RoseDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Wenyu ZhouDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Euan A AshleyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
Stephen B MontgomeryDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA.
Hassan ChaibDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Francois HaddadStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. Electronic address: fhaddad@stanford.edu.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. Electronic address: mpsnyder@stanford.edu.
Stanford University · USCardiovascular Institute of the South · USKing Abdulaziz University · SAThe University of Melbourne · AU
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MStanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5MLongitudinal Multiomics Microbial Profiling in Healthy and Disease IndividualsU54DE023789 · NIDCR · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P., WEINSTOCK, GEORGE M · 2013 to 2014
$3.0MStanford Career Development Program in Omics of Lung DiseasesK12HL120001 · NHLBI · STANFORD UNIVERSITY · PI NICOLLS, MARK ROBERT, RABINOVITCH, MARLENE · 2013 to 2017
$1.3MIntegrating the Exposome into Longitudinal Multiomics ProfilingK08ES028825 · NIEHS · STANFORD UNIVERSITY · PI ROSE, SOPHIA MIRYAM SCHÜSSLER-FIORENZA · 2018 to 2022
$1.0MHigh-throughput sequencer for multi-scale genomic studiesS10OD020141 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2015 to 2015
$600kNHGRI NIH HHS T32 HG000044NHLBI NIH HHS K12 HL120001NIDCR NIH HHS U54 DE023789NIDDK NIH HHS P30 DK116074NIEHS NIH HHS K08 ES028825NIH HHS S10 OD020141
Abstract
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptom-limited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting blood-based biomarkers of peak oxygen consumption.
Indexed as
AgedBiomarkersEnergy MetabolismExerciseFemaleHumansInsulinInsulin ResistanceLeukocytes, MononuclearLongitudinal StudiesMaleMetabolomeMiddle AgedOxygenOxygen ConsumptionProteomeBiomarkersInsulinOxygenProteomecardiopulmonary exercise testingfitnessinsulin resistancemulti-omicsoutlier analysispeak VO(2)physical activitypredictive analyticssystems biologytime-series analysis
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Registered trials
NCT05359744ClinicalTrials.gov
NCT05696652ClinicalTrials.gov
NCT06247774ClinicalTrials.gov
NCT07664540ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.