Evidence map›Paper›PMID 32470374›Full record

ArticleAmerican journal of human genetics2020

A Genetic History of the Near East from an aDNA Time Course Sampling Eight Points in the Past 4,000 Years.

Marc Haber, Joyce Nassar, Mohamed A Almarri, Tina Saupe, Lehti Saag, Samuel J Griffith, Claude Doumet-Serhal, Julien Chanteau, Muntaha Saghieh-Beydoun, Yali Xue and 2 more

Open access · hybridAbstract readHistorical Article
In one paragraph

Article in American journal of human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Imputation of ancient human genomes.Nature communications · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Marc HaberInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK; Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address: m.haber@bham.ac.uk.
Joyce NassarInstitut Français du Proche-Orient, BP 11-1424, Beirut, Lebanon.
Mohamed A AlmarriWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Tina SaupeInstitute of Genomics, University of Tartu, Riia 23b, 51010 Tartu, Estonia; Department of Evolutionary Biology, Institute of Cell and Molecular Biology, University of Tartu, Tartu 51010, Estonia.
Lehti SaagInstitute of Genomics, University of Tartu, Riia 23b, 51010 Tartu, Estonia.
Samuel J GriffithInstitute of Genomics, University of Tartu, Riia 23b, 51010 Tartu, Estonia.
Claude Doumet-SerhalThe Sidon Excavation, Saida, Lebanon.
Julien ChanteauDépartement des Antiquités Orientales, Musée du Louvre, France.
Muntaha Saghieh-BeydounUniversité Libanaise, Rectorat, BP 14-6573, Place du Musée, Beirut, Lebanon.
Yali XueWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Christiana L ScheibInstitute of Genomics, University of Tartu, Riia 23b, 51010 Tartu, Estonia.
Chris Tyler-SmithWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address: cts@sanger.ac.uk.
University of Tartu · EEWellcome Sanger Institute · GBLebanese University · LBLouvre · FROrient-Institut Beirut · LB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The Iron and Classical Ages in the Near East were marked by population expansions carrying cultural transformations that shaped human history, but the genetic impact of these events on the people who lived through them is little-known. Here, we sequenced the whole genomes of 19 individuals who each lived during one of four time periods between 800 BCE and 200 CE in Beirut on the Eastern Mediterranean coast at the center of the ancient world's great civilizations. We combined these data with published data to traverse eight archaeological periods and observed any genetic changes as they arose. During the Iron Age (∼1000 BCE), people with Anatolian and South-East European ancestry admixed with people in the Near East. The region was then conquered by the Persians (539 BCE), who facilitated movement exemplified in Beirut by an ancient family with Egyptian-Lebanese admixed members. But the genetic impact at a population level does not appear until the time of Alexander the Great (beginning 330 BCE), when a fusion of Asian and Near Easterner ancestry can be seen, paralleling the cultural fusion that appears in the archaeological records from this period. The Romans then conquered the region (31 BCE) but had little genetic impact over their 600 years of rule. Finally, during the Ottoman rule (beginning 1516 CE), Caucasus-related ancestry penetrated the Near East. Thus, in the past 4,000 years, three limited admixture events detectably impacted the population, complementing the historical records of this culturally complex region dominated by the elite with genetic insights from the general population.

Indexed as

DNAEgyptEthnicityGenetics, PopulationGenome, HumanHaplotypesHistory, AncientHuman MigrationHumansMiddle EastDNABeirut, Bronze AgeClassical AntiquitycultureIron AgeLebanonmigration, admixturepopulation geneticswhole-genome sequences

Identifiers

PMID32470374
PMCPMC7332655
OpenAlexW3029616474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.