ArticleCurrent biology : CB2020
Low-Dimensional Spatiotemporal Dynamics Underlie Cortex-wide Neural Activity.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 99 citations in OpenAlex.
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- Behavior Differentially Shapes Spontaneous Cortical Network Dynamics Across Frequencies.bioRxiv : the preprint server for biology · 2026Article
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- Causal and directional elements of global brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- A Deterministically Synchronized Widefield Imaging and Virtual Reality Platform for Multimodal Brain-Behavior Recording.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Neural barcoding representing cortical spatiotemporal dynamics based on continuous-time Markov chains.Cell reports methods · 2026Article
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Spontaneously emerging patterns in human motor cortex code for somatotopic specific movements.iScience · 2025Article
- Article
- Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
- Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Low frequency oscillations - neural correlates of stability and flexibility in cognition.Nature communications · 2025Article
- Multiplexed subspaces route neural activity across brain-wide networks.Nature communications · 2025Article
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).Neurobiology of disease · 2025Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- The representation of abstract goals in working memory is supported by task-congruent neural geometry.PLoS biology · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cognition arises from the dynamic flow of neural activity through the brain. To capture these dynamics, we used mesoscale calcium imaging to record neural activity across the dorsal cortex of awake mice. We found that the large majority of variance in cortex-wide activity (∼75%) could be explained by a limited set of ∼14 "motifs" of neural activity. Each motif captured a unique spatiotemporal pattern of neural activity across the cortex. These motifs generalized across animals and were seen in multiple behavioral environments. Motif expression differed across behavioral states, and specific motifs were engaged by sensory processing, suggesting the motifs reflect core cortical computations. Together, our results show that cortex-wide neural activity is highly dynamic but that these dynamics are restricted to a low-dimensional set of motifs, potentially allowing for efficient control of behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.