ArticlePloS one2020
Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up.Journal of clinical medicine · 2026Article
- Resting heart rate and long-term mortality in young adults: a population-based cohort study.Open heart · 2026Article
- Article
- Resting heart rate and cognitive function in ageing: Insights from a secondary data analysis.GeroScience · 2026Article
- Electrocardiographic Predictors of Major Adverse Cardiovascular Events in Women With Suspected Ischemia and no Obstructive Coronary Artery Disease: Results of the Women's Ischemia Syndrome Evaluation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Impact of Controlled Blood Pressure and Pulse Rate at Discharge on Clinical Outcomes in Patients with Non-ST-segment Elevation Myocardial Infarction.Internal medicine (Tokyo, Japan) · 2026Article
- Relationship between minimum heart rate and mortality in ICU patients with traumatic brain injury (TBI): a retrospective analysis based on the MIMIC-IV database.Surgery in practice and science · 2025Article
- Facial video photoplethysmography for measuring average and quasi-instantaneous heart rate: a pilot validation study.Frontiers in physiology · 2025Article
- Comparison of physiological and clinical reactions to COVID-19 and influenza vaccination.Communications medicine · 2024Article
- Cardioneuroablation: the known and the unknown.Frontiers in cardiovascular medicine · 2024Review
- Association between exercise load, resting heart rate, and maximum heart rate and risk of future ST-segment elevation myocardial infarction (STEMI).Open heart · 2023Article
- Minimum heart rate and mortality after cardiac surgery: retrospective analysis of the Multi-parameter Intelligent Monitoring in Intensive Care (MIMIC-III) database.Scientific reports · 2023Article
- Safety of the fourth COVID-19 BNT162b2 mRNA (second booster) vaccine: a prospective and retrospective cohort study.The Lancet. Respiratory medicine · 2023Article
- Resting heart rate is a population-level biomarker of cardiorespiratory fitness: The Fenland Study.PloS one · 2023Article
- Conventional and genetic associations between resting heart rate, cardiac morphology and function as assessed by magnetic resonance imaging: Insights from the UK biobank population study.Frontiers in cardiovascular medicine · 2023Article
- Effect of baseline resting heart rate on the risk of all-cause death in Chinese patients with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Associations of resting heart rate with incident dementia, cognition, and brain structure: a prospective cohort study of UK biobank.Alzheimer's research & therapy · 2022Article
- Estimation of biological heart age using cardiovascular magnetic resonance radiomics.Scientific reports · 2022Article
- Deep neural networks reveal novel sex-specific electrocardiographic features relevant for mortality risk.European heart journal. Digital health · 2022Article
- Sudden cardiac death among Iranian population: a two decades follow-up of Tehran lipid and glucose study.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo define the sex, age, and disease-specific associations of resting heart rate (RHR) with cardiovascular and mortality outcomes in 502,534 individuals from the UK Biobank over 7-12 years of prospective follow-up.
methodsThe main outcomes were all-cause, cardiovascular, and ischaemic heart disease mortality. Additional outcomes included incident acute myocardial infarction (AMI), fatal AMI, and cancer mortality. We considered a wide range of confounders and the effects of competing hazards. Results are reported as hazard ratios (HR) for all-cause mortality and sub-distribution hazard ratios (SHR) for other outcomes with corresponding 95% confidence intervals (CI) per 10bpm increment of RHR.
resultsIn men, for every 10bpm increase of RHR there was 22% (HR 1.22, CI 1.20 to 1.24, p = 3×10-123) greater hazard of all-cause and 17% (SHR 1.17, CI 1.13 to 1.21, p = 5.6×10-18) greater hazard of cardiovascular mortality; for women, corresponding figures were 19% (HR 1.19, CI 1.16 to 1.22, p = 8.9×10-45) and 14% (SHR 1.14, CI 1.07 to 1.22, p = 0.00008). Associations between RHR and ischaemic outcomes were of greater magnitude amongst men than women, but with similar magnitude of association for non-cardiovascular cancer mortality [men (SHR 1.18, CI 1.15-1.21, p = 5.2×10-46); women 15% (SHR 1.15, CI 1.11-1.18, p = 3.1×10-18)]. Associations with all-cause, incident AMI, and cancer mortality were of greater magnitude at younger than older ages.
conclusionsRHR is an independent predictor of mortality, with variation by sex, age, and disease. Ischaemic disease appeared a more important driver of this relationship in men, and associations were more pronounced at younger ages.
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