Evidence map›Paper›PMID 32469990›Full record

ArticlePloS one2020

The social implications of participant choice on adherence to Isonaizid Preventive Therapy (IPT): A follow-up study to high completion rates in Eswatini.

S W Grande, L V Adams, T S B Maseko, E A Talbot, D deGijsel, J Mikal, Z Z Simelane, A Achili, M Mkhontfo, S M Haumba

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

S W GrandeThe Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.ORCID 0000-0002-6796-7991
L V AdamsThe Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.ORCID 0000-0002-1303-2154
T S B MasekoUniversity Research Co. LLC (URC), Mbabane, Eswatini.ORCID 0000-0001-9547-4222
E A TalbotThe Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
D deGijselThe Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.ORCID 0000-0002-7987-7168
J MikalUniversity of Minnesota, School of Public Health, Minneapolis, MN, United States of America.
Z Z SimelaneUniversity Research Co. LLC (URC), Mbabane, Eswatini.
A AchiliUniversity Research Co. LLC (URC), Mbabane, Eswatini.
M MkhontfoUniversity Research Co. LLC (URC), Mbabane, Eswatini.
S M HaumbaUniversity Research Co. LLC (URC), Mbabane, Eswatini.
University of Eswatini · SZDartmouth College · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEswatini (formerly Swaziland) has one of the highest rates of TB and HIV co-disease in the world. Despite national efforts to improve service delivery and prevent TB and HIV transmission, rates remain high. A recent prospective, observational study of integrated, patient-selected IPT delivery showed extraordinary improvements in IPT adherence, running counter to previous assumptions. This prompted the need to understand contextual and unseen study factors that contributed to high rates of adherence.

objectiveTo investigate high rates of IPT adherence rates among people living with HIV who participated in an observational study comparing modes of IPT delivery.

methodsCommunity-based participatory research guided the development of in-person administration of semi-structured questionnaires. Observational and field note data were analyzed. Qualitative data were analyzed using content analysis.

resultsWe interviewed 150 participants and analyzed responses from the 136 who remembered being given a choice of their IPT delivery method. Fifty-seven percent were female and the median age was 42. Nearly 67% of participants chose to receive facility-based IPT. High rates of self-reported IPT treatment adherence were linked to four key concepts: 1) adherence was positively impacted by community education; 2) disclosure of status served to empower participant completion; 3) mode of delivery perceptions positively impacted adherence; and 4) choice of treatment delivery seen as helpful but not essential for treatment completion. DISCUSSION: Achieving higher rates of IPT adherence in Eswatini and similar rural areas requires community-engaged education and outreach in coordination with care delivery systems.

Indexed as

Choice BehaviorPatient PreferenceAdultAmbulatory Care FacilitiesAntitubercular AgentsCommunity-Based Participatory ResearchCommunity Health WorkersComorbidityEswatiniFemaleFollow-Up StudiesHIV InfectionsHouse CallsHumansInterviews as TopicIsoniazidAntitubercular AgentsIsoniazid

Identifiers

PMID32469990
PMCPMC7259658
OpenAlexW3028668676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.