Evidence map›Paper›PMID 32469876›Full record

ArticlePloS one2020

Maternal viral load monitoring: Coverage and clinical action at 4 Kenyan hospitals.

Matthew Sandbulte, Melinda Brown, Catherine Wexler, May Maloba, Brad Gautney, Kathy Goggin, Elizabeth Muchoki, Shadrack Babu, Nicodemus Maosa, Sarah Finocchario-Kessler

Abstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew SandbulteDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America.
Melinda BrownDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America.ORCID 0000-0002-9555-5804
Catherine WexlerDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America.ORCID 0000-0003-1891-9165
May MalobaGlobal Health Innovations, Nairobi, Kenya.
Brad GautneyGlobal Health Innovations, Dallas, TX, United States of America.
Kathy GogginHealth Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, United States of America.
Elizabeth MuchokiKenya Medical Research Institute, Nairobi, Kenya.
Shadrack BabuKenya Medical Research Institute, Nairobi, Kenya.
Nicodemus MaosaKenya Medical Research Institute, Nairobi, Kenya.
Sarah Finocchario-KesslerDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America.

Funding

Piloting at-birth point of care HIV testing strategies in KenyaR01HD076673 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KESSLER, SARAH FINOCCHARIO · 2013 to 2017
$3.4M
Adapting the HITSystem to Support PMTCT Retention and ART AdherenceR34MH107337 · NIMH · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KESSLER, SARAH FINOCCHARIO · 2015 to 2017
$636k
NICHD NIH HHS R01 HD076673NIMH NIH HHS R34 MH107337
6 · The paper itself

Abstract

backgroundKenya's guidelines for prevention of mother-to-child transmission of HIV (PMTCT) recommend routine viral load (VL) monitoring for pregnant and breastfeeding women.

methodWe assessed PMTCT VL monitoring and clinical action occurring between last menstrual period (LMP) and 6 months postpartum at 4 Kenyan government hospitals. Pregnant women enrolled in the HIV Infant Tracking System from May 2016-March 2018 were included. We computed proportions who received VL testing within recommended timeframes and who received clinical action after unsuppressed VL result.

resultsOf 424 participants, any VL testing was documented for 305 (72%) women and repeat VL testing was documented for 79 (19%). Only 115 women (27%) received a guideline-adherent baseline VL test and 27 (6%) received a guideline-adherent baseline and repeat VL test sequence. Return of baseline and repeat VL test results to the facility was high (average 96%), but patient notification of VL results was low (36% baseline and 49% repeat). Clinical action for unsuppressed VL results was even lower: 11 of 38 (29%) unsuppressed baseline results and 2 of 14 (14%) unsuppressed repeat results triggered clinical action. DISCUSSION: Guideline-adherent VL testing and clinical intervention during PMTCT must be prioritized to improve maternal care and reduce the risk of HIV transmission to infants.

Indexed as

MothersViral LoadAdultAnti-HIV AgentsFemaleHIVHospitalsHumansInfantInfectious Disease Transmission, VerticalPregnancyAnti-HIV Agents

Identifiers

PMID32469876
PMCPMC7259657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.