Evidence map›Paper›PMID 32469401›Full record

Observational studyThe American journal of clinical nutrition2020

Race-specific associations of 25-hydroxyvitamin D and parathyroid hormone with cardiometabolic biomarkers among US white and black postmenopausal women.

Jin Xia, Wanzhu Tu, JoAnn E Manson, Hongmei Nan, Aladdin H Shadyab, Jennifer W Bea, Ting-Yuan D Cheng, Lifang Hou, Yiqing Song

Open access · greenAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Jin XiaDepartment of Epidemiology, Indiana University Richard M Fairbanks School of Public Health, Indianapolis, IN, USA.
Wanzhu TuDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hongmei NanDepartment of Epidemiology, Indiana University Richard M Fairbanks School of Public Health, Indianapolis, IN, USA.
Aladdin H ShadyabFamily Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jennifer W BeaUniversity of Arizona Cancer Center, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Ting-Yuan D ChengDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yiqing SongDepartment of Epidemiology, Indiana University Richard M Fairbanks School of Public Health, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USBrigham and Women's Hospital · USIndiana University School of MedicineNorthwestern University · USUniversity of Arizona · USUniversity of California San Diego · USUniversity of Florida · US

Funding

Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among WomenR01HL113056 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI SONG, YIQING · 2013 to 2016
$1.8M
NHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS R01 HL113056
6 · The paper itself

Abstract

backgroundConcentrations of 25-hydroxyvitamin D [25(OH)D] tend to be lower in African Americans than in non-Hispanic whites, but whether adding information on parathyroid hormone (PTH) can help explain the higher cardiometabolic risk among African Americans is unknown.

objectivesThis study examined race (black/white)-specific independent and joint associations of 25(OH)D and PTH with cardiometabolic biomarkers including high-sensitivity C-reactive protein (hs-CRP), estimated glomerular filtration rate (eGFR), and homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-B).

methodsAmong 1500 white and 1300 black postmenopausal women without cardiovascular disease from the Women's Health Initiative Observational Study, a weighted linear regression analysis and a novel penalized spline-based semiparametric model with contour plots, accounting for possible nonlinear relations and interactions simultaneously, were used to investigate the race-specific independent and joint associations of 25(OH)D and PTH with each biomarker.

resultsBlack women had lower concentrations of 25(OH)D and higher PTH, HOMA-IR, HOMA-B, hs-CRP, and eGFR than white women (all P values < 0.0001). Lower 25(OH)D and higher PTH were each independently and jointly associated with higher HOMA-IR in both white and black women, whereas a similar joint relation with HOMA-B was observed in white women only. In contrast, PTH was nonlinearly associated with HOMA-B in black women and positively associated with hs-CRP in white women, independently of 25(OH)D. Whereas there was an inverse linear relation between PTH and eGFR in white women after accounting for 25(OH)D, PTH and 25(OH)D were jointly and nonlinearly associated with eGFR in black women.

conclusionsWe found that the joint association of 25(OH)D and PTH with β-cell function, systemic inflammation, and kidney function apparently differed between white and black women. Further studies are needed to determine whether differences in the vitamin D-PTH endocrine system contribute to racial disparities in cardiovascular health.

Indexed as

AgedBiomarkersBlack or African AmericanCardiovascular DiseasesC-Reactive ProteinFemaleHumansMiddle AgedParathyroid HormonePostmenopauseSpecies SpecificityUnited StatesVitamin DWhite People25-hydroxyvitamin DBiomarkersC-Reactive ProteinParathyroid HormoneVitamin D25-hydroxyvitamin Dcardiometabolic biomarkersjoint associationsparathyroid hormonepostmenopausal womenracial differences

Identifiers

PMID32469401
PMCPMC7398786
OpenAlexW3030987191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.