ArticleeLife2020
Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
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- Plasma proteomic signatures of preclinical Alzheimer's disease biomarkers and memory in clinically unimpaired older adults.medRxiv : the preprint server for health sciences · 2025Article
- Age-related differences in the relationship between sustained attention and associative memory and Memory-Guided inference.Cognitive, affective & behavioral neuroscience · 2025Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Plasma proteomics links brain and immune system aging with healthspan and longevity.Nature medicine · 2025Article
- Synergistic effects ofbioRxiv : the preprint server for biology · 2025Article
- Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.Science advances · 2025Article
- Attending to Remember: Recent Advances in Methods and Theory.Current directions in psychological science · 2025Article
- Differentiation of Related Events in Hippocampus Supports Memory Reinstatement in Development.Journal of cognitive neuroscience · 2025Article
- Neural effects of memory training to reduce false memories in older adults: Univariate and multivariate analyses.Neurobiology of aging · 2025Article
- Memory-guided perception is shaped by dynamic two-stage theta- and alpha-mediated retrieval.Annals of the New York Academy of Sciences · 2025Article
- Intrinsic functional connectivity in medial temporal lobe networks is associated with susceptibility to misinformation.Memory (Hove, England) · 2024Article
- Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation.Science advances · 2024Article
- Article
- Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A 3'UTR Insertion Is a Candidate Causal Variant at theNeurology. Genetics · 2024Article
- A 3'UTR Insertion Is a Candidate Causal Variant at themedRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 1 country.
Funding
Abstract
Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstatement and its relationship to memory behaviour. Moreover, individual differences in the strength of hippocampal activity and cortical reinstatement explained unique variance in performance across multiple assays of episodic memory. These results indicate that fMRI indices of hippocampal pattern completion explain within- and across-individual memory variability in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.