Evidence map›Paper›PMID 32469235›Full record

ArticlePhysiological research2020

Factors affecting the function of the mitochondrial membrane permeability transition pore and their role in evaluation of calcium retention capacity values.

Z Drahota, R Endlicher, O Kučera, D Rychtrmoc, Z Červinková

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Physiological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Z DrahotaDepartment of Physiology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic. wolff@lfhk.cuni.cz.
R Endlicher
O Kučera
D Rychtrmoc
Z Červinková
Charles University · CZUniversity of Hradec Králové · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Values of the calcium retention capacity (CRC) of rat liver mitochondria are highly dependent on the experimental conditions used. When increasing amounts of added calcium chloride are used (1.25-10 nmol), the values of the CRC increase 3-fold. When calcium is added in 75 s intervals, the CRC values increase by 30 % compared with 150 s interval additions. CRC values are not dependent on the calcium/protein ratio in the measured sample in our experimental design. We also show that a more detailed evaluation of the fluorescence curves can provide new information about mitochondrial permeability transition pore opening after calcium is added.

Indexed as

AnimalsBiological TransportCalciumLiverMaleMitochondria, LiverMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePermeabilityRatsResearch DesignCalciumMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition Pore

Identifiers

PMID32469235
PMCPMC8648306
OpenAlexW3032254870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.