Evidence map›Paper›PMID 32469061›Full record

ArticleNucleic acids research2020

FATCAT 2.0: towards a better understanding of the structural diversity of proteins.

Zhanwen Li, Lukasz Jaroszewski, Mallika Iyer, Mayya Sedova, Adam Godzik

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Review
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  8. Genomic and Phenotypic Characterization of Avian-DerivedAnimals : an open access journal from MDPI · 2026
    Article
  9. Article
  10. Sequence and structural alignments reveal insights into ANKLE2 evolution and function.Protein science : a publication of the Protein Society · 2026
    Article
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  16. Review
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  18. Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhanwen LiDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA.
Lukasz JaroszewskiDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA.
Mallika IyerGraduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Mayya SedovaDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA.
Adam GodzikDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA.

Funding

Understanding structural flexibility and evolutionary divergence of proteinsR35GM118187 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GODZIK, ADAM · 2016 to 2020
$1.9M
NIGMS NIH HHS R35 GM118187
6 · The paper itself

Abstract

FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the overall root mean square deviation (RMSD) between the compared structures. This allows to effectively compare protein structures even if they underwent structural rearrangements in different functional forms, different crystallization conditions or as a result of mutations. The major update for the server introduces a new graphical interface, much faster database searches and several new options for visualization of the structural differences between proteins.

Indexed as

SoftwareStructural Homology, ProteinAlgorithmsDatabases, ProteinModels, MolecularProteinsProteins

Identifiers

PMID32469061
PMCPMC7319568

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.