ArticleJournal of the American Heart Association2020
Tetrodotoxin-Sensitive Neuronal-Type Na
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 17 citations in OpenAlex.
- Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Small-conductance CaThe Journal of physiology · 2026Review
- Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026Article
- Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels.Nature communications · 2026Article
- Selectivity Filter Mutation in NaJACC. Clinical electrophysiology · 2026Article
- Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.Circulation research · 2026Article
- Blood nerve barrier permeability enables nerve targeting of circulating nanoparticles in experimental autoimmune neuritis.Scientific reports · 2025Article
- Acute GLP-1 Agonism Induces Arrhythmogenic Electrical Activity in Aged Mice Heart Through Impaired Cellular Na+ and Ca2+ Handlings: The Role of CK2 Hyperphosphorylation.Anatolian journal of cardiology · 2025Article
- Riluzole is associated with reduced risk of heart failure.European journal of neurology · 2025Article
- Association of atrial fibrillation with lamotrigine: An observational cohort study.Pharmacotherapy · 2025Observational
- A Novel Computational Platform for Optimizing Synergistic Drug Combinations for Cardioversion of Atrial Fibrillation.JACC. Clinical electrophysiology · 2024Article
- Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.Nature communications · 2024Article
- A Possible Role of Tetrodotoxin-Sensitive NaInternational journal of molecular sciences · 2024Article
- Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults.JACC. Clinical electrophysiology · 2024Article
- Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024Review
- NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.The Journal of clinical investigation · 2023Article
- Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?Pharmaceuticals (Basel, Switzerland) · 2022Review
- Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature.Frontiers in cardiovascular medicine · 2022Article
- Tetrodotoxin-Sensitive Neuronal-Type NaJournal of the American Heart Association · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 2 countries.
Mark A MungerDepartments of Pharmacotherapy and Internal Medicine University of Utah Health Sciences Center Salt Lake City UT.
Yusuf OlğarDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Megan L KoleskeDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Heather L StruckmanDepartment of Biomedical Engineering College of Engineering The Ohio State University Columbus OH.
Jessica MandrioliDepartment of Neuroscience St. Agostino Estense Hospital Azienda Ospedaliero Universitaria di Modena Italy.
Qing LouDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Ingrid BonilaDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Kibum KimDepartment of Pharmacotherapy University of Utah Health Sciences Center Salt Lake City UT.
Roberto Ramos MondragonDepartment of Internal Medicine and of Molecular & Integrative Physiology University of Michigan Ann Arbor MI.
Silvia G PrioriMolecular Cardiology Istituti Clinici Scientifici Maugeri IRCCS University of Pavia Italy.
Pompeo VolpeDepartment of Biomedical Sciences University of Padova Italy.
Héctor H ValdiviaDepartment of Internal Medicine and of Molecular & Integrative Physiology University of Michigan Ann Arbor MI.
Joseph BiskupiakDepartment of Pharmacotherapy University of Utah Health Sciences Center Salt Lake City UT.
Cynthia A CarnesDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Rengasayee VeeraraghavanDepartment of Biomedical Engineering College of Engineering The Ohio State University Columbus OH.
Sándor GyörkeDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
Przemysław B RadwańskiDorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Wexner Medical Center Columbus OH.
The Ohio State University · USThe Ohio State University Wexner Medical Center · USUniversity of Utah · USUniversity of Michigan–Ann Arbor · USAzienda Unita' Sanitaria Locale Di Modena · ITUniversity of Padua · ITUniversity of Pavia · IT
Funding
CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTR01HL063043 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Sandor Gyorke · 1999 to 2026
$8.6MRyanodine Receptor Channels in Heart FailureR01HL074045 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GYORKE, SANDOR · 2003 to 2024
$8.2MMicrodomain regulation of Ca2+ release in cardiac physiology and diseaseR00HL127299 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2017 to 2019
$740kMicrodomain regulation of Ca2+ release in cardiac physiology and diseaseK99HL127299 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2015 to 2016
$233kNHLBI NIH HHS K99 HL127299NHLBI NIH HHS R00 HL127299NHLBI NIH HHS R01 HL063043NHLBI NIH HHS R01 HL074045
Abstract
Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca
Indexed as
AdultAnimalsAnti-Arrhythmia AgentsAtrial FibrillationCalcium SignalingCardiac Pacing, ArtificialCatecholaminesDisease Models, AnimalDogsFemaleHeart FailureHeart RateHumansItalyMaleMembrane PotentialsAnti-Arrhythmia AgentsCatecholaminesRiluzoleRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerSodium Channel BlockersSodium ChannelsTetrodotoxinatrial arrhythmiasatrial fibrillationcardiac arrhythmiasneuronal‐type Na+ channel blockade
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What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.