ArticleJournal of biophotonics2020
Visibility of microvessels in Optical Coherence Tomography angiography depends on angular orientation.
Article in Journal of biophotonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Bessel beam optical coherence microscopy enables multiscale assessment of cerebrovascular network morphology and function.Light, science & applications · 2024Article
- Adaptive vessel tracing and segmentation in OCT enables the robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice.Biomedical optics express · 2023Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Blood vessel tail artifacts suppression in optical coherence tomography angiography.Neurophotonics · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- Numerical calibration method for a multiple spectrometer-based OCT system.Biomedical optics express · 2022Article
- Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry.Biomedical optics express · 2021Article
- Association between non-culprit healed plaque and plaque progression in acute coronary syndrome patients: an optical coherence tomography study.Journal of geriatric cardiology : JGC · 2021Article
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography.Scientific reports · 2020Article
- Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms.Biomedical optics express · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Optical Coherence Tomography angiography (OCTA) is a widespread tool for depth-resolved imaging of chorioretinal vasculature with single microvessel resolution. To improve the clinical interpretation of OCTA, the conditions affecting visualization of microvessels must be defined. Here we inject a scattering plasma tracer (Intralipid) during OCTA imaging of the anesthetized rat eye. In the retina, we find that interlaminar (vertical) vessels that connect laminae have one-fourth to one-third the OCTA red blood cell to tracer (RBC-to-tracer) signal ratio of intralaminar (horizontal) vessels. This finding suggests that the OCTA signal from microvessels depends on angular orientation, making vertically-oriented vessels more difficult to visualize using intrinsic contrast alone. Clinicians should be aware of this potential artifact when interpreting OCTA.
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Registered trials
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