Evidence map›Paper›PMID 32468656›Full record

ArticleAging cell2020

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles.

James Matthew Hinkley, Heather H Cornnell, Robert A Standley, Emily Y Chen, Niven R Narain, Bennett P Greenwood, Valerie Bussberg, Vladimir V Tolstikov, Michael A Kiebish, Fanchao Yi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Recent Advances in Musculoskeletal Radiology: Bridging Innovation and Clinical Application.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Chronic alcohol intake elicits distinct multi-omic profiles in the liverbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Differential transcriptomic profiling of lipid metabolism and collagen remodeling in fast- and slow-twitch skeletal muscles in aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. LC/MS-Based Untargeted Lipidomics Reveals Lipid Signatures of Sarcopenia.International journal of molecular sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

James Matthew HinkleyAdventHealth Translational Research Institute, Orlando, FL, USA.
Heather H CornnellAdventHealth Translational Research Institute, Orlando, FL, USA.
Robert A StandleyAdventHealth Translational Research Institute, Orlando, FL, USA.
Emily Y ChenBERG Health, Framingham, MA, USA.
Niven R NarainBERG Health, Framingham, MA, USA.
Bennett P GreenwoodBERG Health, Framingham, MA, USA.
Valerie BussbergBERG Health, Framingham, MA, USA.
Vladimir V TolstikovBERG Health, Framingham, MA, USA.
Michael A KiebishBERG Health, Framingham, MA, USA.
Fanchao YiAdventHealth Translational Research Institute, Orlando, FL, USA.
Rick B VegaAdventHealth Translational Research Institute, Orlando, FL, USA.
Bret H GoodpasterAdventHealth Translational Research Institute, Orlando, FL, USA.
Paul M CoenAdventHealth Translational Research Institute, Orlando, FL, USA.ORCID 0000-0002-2805-2115
Translational Research Institute for Metabolism and Diabetes · US

Funding

Skeletal Muscle Lipid and Insulin Resistance in AgingR01AG021961 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOODPASTER, BRET H · 2004 to 2015
$4.1M
Ceramide Mediated Oxidative Stress in Muscle Loss with Aging and DisuseK01AG044437 · NIA · ADVENTHEALTH ORLANDO · PI COEN, PAUL MARTIN · 2013 to 2016
$508k
NIA NIH HHS K01 AG044437NIA NIH HHS R01 AG021961
6 · The paper itself

Abstract

The loss of skeletal muscle mass and function with age (sarcopenia) is a critical healthcare challenge for older adults. 31-phosphorus magnetic resonance spectroscopy (

Indexed as

AgedFemaleHumansMaleMuscle, SkeletalOligonucleotidesPhosphocreatinePhospholipidsSarcopeniaOligonucleotidesPhosphocreatinephosphodiester alphaPhospholipidsagingmuscle volumepeak powerphosphatidylcholinephosphatidylethanolaminephosphodiester

Identifiers

PMID32468656
PMCPMC7294783
OpenAlexW3032423329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.