ArticleAnnals of the New York Academy of Sciences2020
Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy.
Article in Annals of the New York Academy of Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Maternal sleep during pregnancy and adverse pregnancy outcomes: A systematic review and meta-analysis.Journal of diabetes investigation · 2022Pooled it
- Inflammatory exposures in early pregnancy and multidimensional sleep in late pregnancy: a prospective population-based study.Brain, behavior, & immunity - health · 2026Article
- Inflammation, sleep, and trait mindfulness in pregnancy.Sleep health · 2026Article
- Cardiometabolic Health in Pregnancy: Prevention, Management, and Long-Term Implications.JACC. Advances · 2026Review
- Dietary characteristics associated with hemoglobin and anemia among prospective first-time voluntary blood donors in Accra, Ghana.BMC nutrition · 2026Article
- Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring.Journal of sleep research · 2025Review
- Daily changes in sleep stages and associated cardiovascular parameters during pregnancy: using a wearable device.Frontiers in global women's health · 2025Article
- Associations of lifestyle characteristics with circulating immune markers in the general population based on NHANES 1999 to 2014.Scientific reports · 2024Article
- Obstructive Sleep Apnea in Pregnancy: A Comprehensive Review of Maternal and Fetal Implications.Neurology international · 2024Review
- Effects of Gestational Intermittent Hypoxia on Placental Morphology and Fetal Development in a Murine Model of Sleep Apnea.Advances in experimental medicine and biology · 2023Article
- Dietary Inflammatory Index and sleep quality and duration among pregnant women with overweight or obesity.Sleep · 2022Article
- Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals.Sleep medicine · 2022Article
- Longitudinal changes in objective sleep parameters during pregnancy.Women's health (London, England)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy-four women underwent an overnight sleep assessment by polysomnography. Blood samples were collected before bedtime and again within 1 h upon awakening to measure C-reactive protein (CRP), interleukin (IL)-6, and IL-6 soluble receptor. Sleep parameters included variables characterizing sleep architecture and sleep continuity. The participants were 32.2 (SD = 4.1) years old, and the average gestational age was 32.8 (3.5) weeks. Controlling for covariates, evening CRP was negatively associated with N3 sleep (β = -0.30, P = 0.010). N3 sleep was also negatively associated with morning CRP (β = -0.26, P = 0.036), with a higher percentage of N3 sleep associated with a lower level of morning CRP. Contrarily, there was a tendency for a positive association between stage N2 sleep and morning CRP (β = 0.23, P = 0.065). Stage N1 sleep was associated with morning IL-6 (β = 0.28, P = 0.021), with a higher percentage of N1 sleep associated with a higher morning IL-6. No significant associations were found between morning inflammatory biomarkers and sleep continuity parameters. In conclusion, increased light sleep was associated with increased inflammatory biomarkers, whereas more deep sleep was associated with decreased inflammatory biomarkers. These findings further support the interactions between sleep and the immune system during late pregnancy.
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