Evidence map›Paper›PMID 32468614›Full record

ReviewHuman brain mapping2020

The ENIGMA-Epilepsy working group: Mapping disease from large data sets.

Sanjay M Sisodiya, Christopher D Whelan, Sean N Hatton, Khoa Huynh, Andre Altmann, Mina Ryten, Annamaria Vezzani, Maria Eugenia Caligiuri, Angelo Labate, Antonio Gambardella and 63 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Christopher D WhelanDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Sean N HattonCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-9149-8726
Khoa HuynhCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.
Andre AltmannCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID https://orcid.org/0000-0002-9265-2393
Mina RytenUCL Queen Square Institute of Neurology, London, UK.
Annamaria VezzaniDepartment of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Maria Eugenia CaligiuriNeuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-2030-5552
Angelo LabateNeuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-8827-7324
Antonio GambardellaNeuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0001-7384-3074
Victoria Ives-DeliperiNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Stefano MelettiDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0003-0334-539X
Brent C MunsellDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Leonardo BonilhaDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
Manuela TondelliNeurology Unit, OCB Hospital, AOU Modena, Modena, Italy.
Michael RebsamenSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8441-1485
Christian RummelSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-2345-7938
Anna Elisabetta VaudanoDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0002-6280-7526
Roland WiestSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Akshara R BalachandraCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.
Núria BargallóMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0001-6284-5402
Emanuele BartoliniNeurology Unit, USL Centro Toscana, Nuovo Ospedale Santo Stefano, Prato, Italy.ORCID https://orcid.org/0000-0002-5683-1941
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
Neda BernasconiNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
Boris BernhardtMcConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.ORCID https://orcid.org/0000-0001-9256-6041
Benoit CaldairouNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
Sarah J A CarrNeuroscience, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Gianpiero L CavalleriSchool of Pharmacy and Biomolecular Sciences, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Fernando CendesDepartment of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9336-9568
Luis ConchaInstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
Patricia M DesmondDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Martin DominFunctional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Niels K FockeUniversity Medicine Göttingen, Clinical Neurophysiology, Göttingen, Germany.ORCID https://orcid.org/0000-0001-5486-6289
Renzo GuerriniPediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Khalid HamandiThe Wales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.ORCID https://orcid.org/0000-0001-7116-262X
Graeme D JacksonDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0000-0002-7917-5326
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Reetta KälviäinenKuopio University Hospital, Member of EpiCARE ERN, Kuopio, Finland.
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-5247-9795
Peter KochunovDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Magdalena A KowalczykFlorey Department of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-5410-0299
Barbara A K KreilkampInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-6881-5191
Patrick KwanDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Sara LariviereMcConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
Matteo LengePediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-2848-621X
Seymour M LopezCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Pascal MartinDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany.
Mario Mascalchi'Mario Serio' Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.
José C V MoreiraDepartment of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
Marcia E Morita-ShermanDepartment of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-8531-3916
Heath R PardoeDepartment of Neurology, New York University School of Medicine, New York, New York, USA.
Jose C ParienteMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
Kotikalapudi RavitejaDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0003-4604-3367
Cristiane S RochaDepartment of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
Raúl Rodríguez-CrucesInstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.ORCID https://orcid.org/0000-0002-2917-1212
Margitta SeeckEEG and Epilepsy Unit, Geneva, Switzerland.
Mira K H G SemmelrochFlorey Department of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.
Benjamin SinclairDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Hamid Soltanian-ZadehRadiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-7302-6856
Dan J SteinSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Townon Risk & Resilience in Mental Disorders, Cape Town, South Africa.
Pasquale StrianoPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto 'G. Gaslini', Genova, Italy.ORCID https://orcid.org/0000-0002-6065-1476
Peter N TaylorSchool of Computing, Newcastle University, Newcastle upon Tyne, UK.
Rhys H ThomasInstitute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.ORCID https://orcid.org/0000-0002-0046-4070
Dennis VelakoulisDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, UK.
Lucy VivashDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
Clarissa Lin YasudaDepartment of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
Junsong ZhangCognitive Science Department, School of Informatics, Xiamen University, Xiamen, China.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Carrie R McDonaldDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
ENIGMA Consortium Epilepsy Working Group

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Lifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8M
Predicting Epilepsy Surgery Outcomes Using Neural Network ArchitectureR01NS110347 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BONILHA, LEONARDO F, DRANE, DANIEL L · 2019 to 2023
$3.6M
High resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
Prediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy studyR21NS107739 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONILHA, LEONARDO F, MCDONALD, CARRIE R · 2019 to 2019
$444k
CIHR FDN-154298CIHR MOP-123520; MOP-130516CIHR MOP-57840Department of HealthDeutsche Forschungsgemeinschaft (DFG) FO750/5-1Epilepsy Research UK 1085European Regional Development FundEuropean Union 602102FAPESPFAPESP-BRAINN 07559-3FAPESP-BRAINN 2013/07559-3FAPESP-BRAINN 2013/07599-3FAPESP-BRAINN 403726/2016-6FRQSHealth Research BoardMedical Research Council L016311/1Medical Research Council MR/K013998/1Medical Research Council MR/K023152/1Medical Research Council MR/L016311/1Medical Research Council MR/N008324/1Medical Research Council MR/S00355X/1Medical Research Council MR/S00355X/1; MR/K023152/1Mexican Council of Science and Technology 181508; 232676; 251216; 280283Ministry of Health NET-2013-02355313Monash UniversityNational Health and Medical Research Council 1081151National Health and Medical Research Council 1091593National Health and Medical Research Council R01 AG059874; R01 MH117601National Health and Medical Research Council S10OD023696; R01EB015611National Institute for Health Research (NIHR)National Nature Science Foundation of China 61772440NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIHNIH HHS S10 OD023696NIH/NINDS R01NS110347NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH118514NINDS NIH HHS 1R21NS107739-01A1NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS110347NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739NSERC Discovery-1304413São Paulo Research Foundation 2013/07559-3Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung (SNF) 163398Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung (SNF) 180365Science Foundation Ireland 16/RC/3948; 08/RFP/GEN1538SickKids Foundation NI17-039South African Medical Research CouncilSwiss National Science Foundation 180365Tenure-track Clinician Scientist Fellowship MR/N008324/1UNAM-DGAPA IB201712University of Melbourne MRFF1136427University of Tübingen F1315030University of Tübingen R01 NS065838; R21 NS107739
6 · The paper itself

Abstract

Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy.

Indexed as

covariancedeep learningDTIevent-based modelinggene expressiongeneticsimagingMRIquantitativersfMRI

Identifiers

PMID32468614
PMCPMC8675408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.