SynthesisClinical oral investigations2020
Preoperative oral pregabalin for anxiety control: a systematic review.
Synthesis in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.Molecular psychiatry · 2022Pooled it
- Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.Anesthesia and analgesia · 2026Trial
- Evaluation of the effects of pregabalin and dexamethasone coadministration on preemptive multimodal analgesia and anxiety in third molar surgeries: a triple-blind randomized clinical trial.Clinical oral investigations · 2024Trial
- The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo.Scientific reports · 2023Trial
- Is there any difference between oral preemptive pregabalin vs. placebo administration on response to EBUS-TBNA under sedation?Turkish journal of medical sciences · 2021Trial
- Randomized, double-blind trial of preoperative pregabalin versus placebo to improve quality of recovery after breast cancer surgery.Brazilian journal of anesthesiology (Elsevier)Trial
- Preoperative Oral Tasipimidine in Dogs Undergoing Elective Ovariectomy: Anxiolysis, Handling Quality and Cardiovascular Effects.Veterinary sciences · 2026Article
- Pregabalin contributes to increased recovery time from isoflurane anaesthesia for magnetic resonance imaging in horses.Equine veterinary journal · 2026Article
- Perioperative Anxiety and Stress Cortisol on Postoperative Pain: Pharmacological and Non-Pharmacological Management Strategies.Journal of surgery and research · 2026Article
- The Effect of Pregabalin on Preoperative Anxiety and Postoperative Pain in Patients Undergoing Percutaneous Nephrolithotomy: A Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2025Article
- Comparison of Pregabalin and Midazolam as Premedication in Children Undergoing General Anesthesia for Dental Treatment.Anesthesiology and pain medicine · 2024Article
- Pregabalin Alleviates Anxiety and Fear in Cats during Transportation and Veterinary Visits-A Clinical Field Study.Animals : an open access journal from MDPI · 2023Article
- Perioperative pregabalin reduced fatigue scores after thoracoscopic pneumonectomy in a RCT of NSCLC patients.American journal of cancer research · 2023Article
- A bibliometric analysis of preoperative anxiety research (2001-2021).Frontiers in pediatrics · 2022Article
- The effect of pregabalin on postdural puncture headache among patients undergoing elective cesarean section: A randomized controlled trial.Annals of medicine and surgery (2012) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this systematic review was to determine the effectiveness of preoperative oral pregabalin for anxiety control, the most effective dosage regimen, its impact on postoperative pain, and its adverse effects. MATERIALS AND
methodsA search was conducted of PubMed/Medline and clinicaltrials.gov (National Library of Medicine, Washington, DC), Scopus, Web of Science, and Cochrane databases for studies published between January 2009 and November 2018, with no language restriction. Based on PRISMA guidelines, the specific question was: is preoperative oral pregabalin effective and safe for anxiety control in patients undergoing surgery? The critical reading of retrieved studies followed questions prepared by the CASPe Network, and their methodological quality was evaluated using the Jadad Scale.
resultsTwelve randomized controlled trials were selected for review. All twelve studies were trials of high quality. A dose of 75 mg preoperative oral pregabalin has been found to reduce anxiety and stabilize intraoperative hemodynamics, although a more significant improvement appears to be achieved with a single dose of 150 mg pregabalin at least 1 h before the surgery. It is not associated with any severe adverse effects.
conclusionPreoperative administration of oral pregabalin in a single dose of 150 mg appears to be effective to significantly reduce the anxiety of patients, intraoperative hemodynamic changes, and postoperative pain. CLINICAL RELEVANCE: These findings suggest that pregabalin is useful and safe for preoperative and intraoperative anxiety control in patients undergoing surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.