Evidence map›Paper›PMID 32468460›Full record

ArticleAdvances in experimental medicine and biology2020

Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders.

Sofia Raftopoulou, Nicolas C Nicolaides, Louis Papageorgiou, Anastasia Amfilochiou, Spyros G Zakinthinos, Potamitis George, Elias Eliopoulos, George P Chrousos, Dimitrios Vlachakis

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Article in Advances in experimental medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Sofia RaftopoulouGenetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece.
Nicolas C NicolaidesDivision of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Louis PapageorgiouGenetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece.
Anastasia AmfilochiouSismanoglio General Hospital of Attica, Respiratory Function & Sleep Study Unit, Marousi, Greece.
Spyros G ZakinthinosCritical Care and Pulmonary Services, Evangelismos Hospital, Medical School of Athens University, Athens, Greece.
Potamitis GeorgeAffidea Healthcare Company, Athens, Greece.
Elias EliopoulosGenetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece.
George P ChrousosDivision of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Dimitrios VlachakisGenetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece. dimvl@aua.gr.
Academy of Athens · GRAgricultural University of Athens · GRNational and Kapodistrian University of Athens · GREvangelismos Hospital · GRGeneral Hospital of Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we deploy an in silico pipeline of structural bioinformatics, thermodynamics, and molecular dynamics to investigate the role of cortisol in circadian rhythms, biorhythms, stress response, and even sleep disorders. Our study shows that high concentrations of cortisol intercalate in the minor groove of DNA. This phenomenon widens the adjacent major grooves and provides the Clock/Bmal1 complex with more space to dock and interact with DNA. Then, the strong charges of cortisol pull the alpha helices of the Clock/Bmal1 complex and bend it inward, thus establishing stronger interactions and prolonged signaling. Our results indicate that elevated cortisol levels play an important role in stress, inflammation, and sleep disorders as a result of prolonged and stronger dsDNA - Clock/Bmal1 interactions.

Indexed as

ARNTL Transcription FactorsCircadian RhythmCLOCK ProteinsComputer SimulationDNAHumansHydrocortisoneHypothalamo-Hypophyseal SystemInflammationIntercalating AgentsPituitary-Adrenal SystemReceptors, GlucocorticoidSleep Wake DisordersStress, PsychologicalARNTL Transcription FactorsCLOCK ProteinsDNAHydrocortisoneIntercalating AgentsReceptors, GlucocorticoidCell SignalingCortisolDNA intercalationGeneticsHypothalamic-pituitary-adrenal (HPA) axisInflammationSleep disordersStress

Identifiers

PMID32468460
OpenAlexW3031904665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.