Evidence map›Paper›PMID 32468456›Full record

ReviewAdvances in experimental medicine and biology2020

Three-Dimensional Models for Studying Neurodegenerative and Neurodevelopmental Diseases.

Stavroula Tsaridou, Margarita Skamnelou, Marianna Iliadou, Georgia Lokka, Evangelia Parlapani, Maria Mougkogianni, Rodolfos-Iosif Danalatos, Anastasia Kanellou, Dimitris-David Chlorogiannis, Christina Kyrousi and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stavroula TsaridouBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Margarita SkamnelouBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Marianna IliadouBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Georgia LokkaBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Evangelia ParlapaniBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Maria MougkogianniBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Rodolfos-Iosif DanalatosBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Anastasia KanellouBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece.
Dimitris-David ChlorogiannisDepartment of Physiology, School of Medicine, University of Patras, Patras, Greece.
Christina KyrousiDepartment of Physiology, School of Medicine, University of Patras, Patras, Greece.
Stavros TaravirasBiomedical Postgraduate Programme, Stem Cells and Regenerative Medicine, Medical School, University of Patras, Patras, Greece. taraviras@med.upatras.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human brain possesses a unique anatomy and physiology. For centuries, methodological barriers and ethical challenges in accessing human brain tissues have restricted researchers into using 2-D cell culture systems and model organisms as a tool for investigating the mechanisms underlying neurological disorders in humans. However, our understanding regarding the human brain development and diseases has been recently extended due to the generation of 3D brain organoids, grown from human stem cells or induced pluripotent stem cells (iPSCs). This system evolved into an attractive model of brain diseases as it recapitulates to a great extend the cellular organization and the microenvironment of a human brain. This chapter focuses on the application of brain organoids in modelling several neurodevelopmental and neurodegenerative diseases.

Indexed as

BrainHumansInduced Pluripotent Stem CellsNeurodegenerative DiseasesNeurodevelopmental DisordersOrganoidsNeurodegenerative diseaseNeurodevelopmental diseasesThree-dimensional models

Identifiers

PMID32468456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.