ArticleJournal of materials science. Materials in medicine2020
The outcome of biphasic calcium phosphate bone substitute in a medial opening wedge high tibial osteotomy.
Article in Journal of materials science. Materials in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Effectiveness of bone substitute materials in opening wedge high tibial osteotomy: a systematic review and meta-analysis.Annals of medicine · 2022Pooled it
- Clinical and radiological results of allogenous bone graft versus synthetic calcium-phosphate graft in opening wedge high tibial osteotomy.Journal of experimental orthopaedics · 2026Article
- Moldable self-setting and bioactive bone wax for bone hemostasis and defect repair.Journal of orthopaedic translation · 2025Article
- Bone Healing and Clinical Outcome Following Medial Opening-wedge High Tibial Osteotomy Using Wedge-Shaped Cancellous Allograft.Orthopaedic surgery · 2024Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Silicate/zinc-substituted strontium apatite coating improves the osteoinductive properties of β-tricalcium phosphate bone graft substitute.BMC musculoskeletal disorders · 2021Article
- Combination of Cylindrical Autologous Bone Grafting Technique With a Metallic Block Insertion in Open-Wedge High Tibial Osteotomy.Arthroscopy techniques · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur objective was to assess clinical and radiological findings following a medial opening wedge high tibial osteotomy using a biphasic calcium phosphate (BCP) synthetic bone substitute, designed as a wedge with two differing zones of density. The in-vivo behaviour of this type of bone substitute over time is currently unknown. HYPOTHESIS: Our hypothesis was that BCP synthetic bone would facilitate bone union and undergo replacement with host bone over the study period. PATIENTS AND
methodsFifteen sequential patients were followed prospectively for minimum 4-years post-operatively. All patients were evaluated clinically using patient reported outcome measures and radiologically to evaluate alignment with maintenance of the osteotomy correction, and bone union with expected BCP dissolution.
resultsAll patients had good clinical scores with no reported complications at 4 years. In all cases there were radiographic findings of bone union with consolidation and no loss of correction. However the graft remained densely radiopaque at final follow-up. DISCUSSIONS: This study demonstrates that a BCP graft in combination with a locking plate for a medial opening wedge HTO allows early weight-bearing, maintains correction and provides good clinical outcomes. Whilst higher densities of BCP are strong, they do not resorb fully, remaining radiographically visible. This may have implications for the performance of a future knee arthroplasty and caution should therefore be taken.
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