Evidence map›Paper›PMID 32468398›Full record

ArticleNeuroscience bulletin2021

Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus-preBötzinger Complex Circuit.

Na Liu, Congrui Fu, Hongxiao Yu, Yakun Wang, Luo Shi, Yinchao Hao, Fang Yuan, Xiangjian Zhang, Sheng Wang

Open access · greenAbstract read
In one paragraph

Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Central respiratory chemoreception.Handbook of clinical neurology · 2022
    Review
  14. Adolescent Congenital Central Hypoventilation Syndrome: An Easily Overlooked Diagnosis.International journal of environmental research and public health · 2021
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Na Liu *Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Congrui Fu *School of Nursing, Hebei Medical University, Shijiazhuang, 050000, China.
Hongxiao Yu *Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yakun WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Luo ShiDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yinchao HaoDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Fang YuanDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Xiangjian ZhangHebei Key laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang, 050000, China.
Sheng WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China. wangsheng@hebmu.edu.cn.ORCID http://orcid.org/0000-0001-9579-4808
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The locus coeruleus (LC) has been implicated in the control of breathing. Congenital central hypoventilation syndrome results from mutation of the paired-like homeobox 2b (Phox2b) gene that is expressed in LC neurons. The present study was designed to address whether stimulation of Phox2b-expressing LC (Phox2b

Indexed as

Homeodomain ProteinsLocus CoeruleusAnimalsDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsHumansMiceNeuronsRespirationTranscription FactorsDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsHomeodomain ProteinsPhox2b protein, mousePREB protein, humanTranscription FactorsChemoreceptorHypercapnic ventilatory responseLocus coeruleusNeural circuitPhox2b

Identifiers

PMID32468398
PMCPMC7811975
OpenAlexW3030939511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.