ReviewDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2020
[Pruritus-a long journey from neurophysiology to the clinic].
Review in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 0 citations in OpenAlex.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mutual exchange of results between basic sciences and clinical research as well as their translation into practice, also with regard to chronic pruritus, is currently to be seen as an ambition or hope rather than established practice.
objectiveIn view of the rapid developments in the field of neurophysiological basics of pruritus, the aim is to clarify how these new concepts can be brought in line with clinical understanding. MATERIALS AND
methodsA review is provided.
resultsAfter the peripheral and spinal processing pathways for pruritus in the mouse were characterized with molecular markers, we are currently working on the translation of this information to the only functionally defined nerve fiber classes in humans. However, it is still unclear whether these processing pathways are crucial for the explanation of chronic pruritus in patients, since inflammation or neuropathy can significantly alter nerve populations and neuronal networks. Therefore, molecular target structures, which have emerged from results of basic research, need to be verified in patients. The gold standard, however, remains the patient with clinical observation and testing. Specific stimulation methods from neurophysiology can help to test hypotheses from basic research directly on patients, while also providing impulses for further development of research concepts.
conclusionsTranslation in medical research is now perceived by many researchers as a hackneyed buzzword. In the field of pruritus research, however, the exchange of results and concepts based on the mutual appreciation of expertise appears attractive, highly relevant, and promising.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.