Evidence map›Paper›PMID 32468273›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2020

An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.

Ann-Cathrine Berking, Christiane Thiel, Miriam A Schiele, Christian Baumann, Raffael Kalisch, Swantje Notzen, Peter Zwanzger, Christiane A Pané-Farré, Alfons Hamm, Georg W Alpers and 17 more

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 15 institutions in 1 country.

Ann-Cathrine BerkingDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Margarete-Höppel Platz 1, 97080, Würzburg, Germany.ORCID 0000-0003-2658-4211
Christiane ThielDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Miriam A SchieleDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Christian BaumannDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Margarete-Höppel Platz 1, 97080, Würzburg, Germany.
Raffael KalischNeuroimaging Center (NIC), Johannes Gutenberg University Medical Center, Mainz, Germany.
Swantje NotzenCatholic University of Applied Science Münster, Münster, Germany.
Peter ZwanzgerDepartment of Psychiatry and Psychotherapy, District Hospital Gabersee, Wasserburg am Inn, Germany.
Christiane A Pané-FarréInstitute of Psychology, University of Greifswald, Greifswald, Germany.
Alfons HammInstitute of Psychology, University of Greifswald, Greifswald, Germany.
Georg W AlpersDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Thomas FydrichInstitute of Psychology, Humboldt University, Berlin, Germany.
Lydia FehmInstitute of Psychology, Humboldt University, Berlin, Germany.
Alexander L GerlachInstitute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University Hospital of Marburg, Marburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University Hospital of Marburg, Marburg, Germany.
Winfried RiefInstitute of Psychology, Philipps University Marburg, Marburg, Germany.
Jens PlagDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Campus Charité Mitte, Berlin, Germany.
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Campus Charité Mitte, Berlin, Germany.
Thomas LangChristoph-Dornier-Foundation for Clinical Psychology, Bremen, Germany.
Hans-Ulrich WittchenInstitute of Clinical Psychology and Psychotherapy, TU Dresden, Dresden, Germany.
Volker AroltDepartment of Psychiatry, University of Münster, Münster, Germany.
Marcel RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Paul PauliDepartment of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), Center of Mental Health, University of Würzburg, Würzburg, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Frankfurt, Germany.
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Margarete-Höppel Platz 1, 97080, Würzburg, Germany.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Heike WeberDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Margarete-Höppel Platz 1, 97080, Würzburg, Germany. Weber_H@ukw.de.
Philipps University of Marburg · DEUniversitätsklinikum Würzburg · DEUniversity of Freiburg · DEUniversity of Münster · DECharité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DEUniversity of Würzburg · DEDornier Flugzeugwerke (Germany) · DEGoethe University Frankfurt · DEJohannes Gutenberg University Mainz · DELMU Klinikum · DEMedizinische Hochschule Hannover · DEUniversität Greifswald · DEUniversity of Cologne · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation-DNA methyltransferases (DNMTs)-has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic disorder, 506 panic disorder patients and 3112 healthy participants were assessed for anxiety related cognition [Agoraphobic Cognitions Questionnaire (ACQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] as well as pathological worry [Penn State Worry Questionnaire (PSWQ)] and genotyped for five single nucleotide polymorphisms (SNPs) in the DNMT3A (rs11683424, rs1465764, rs1465825) and DNMT3B (rs2424932, rs4911259) genes, which have previously been found associated with clinical and trait-related phenotypes. There was no association with the categorical phenotype panic disorder. However, a significant association was discerned between DNMT3A rs1465764 and PSWQ scores in healthy participants, with the minor allele conveying a protective effect. In addition, a marginally significant association between questionnaire scores (PSWQ, ASI) in healthy participants and DNMT3B rs2424932 was detected, again with the minor allele conveying a protective effect. The present results suggest a possible minor role of DNMT3A and DNMT3B gene variation in conveying resilience towards anxiety disorders. As the observed associations indicated a protective effect of two SNPs particularly with pathological worry, future studies are proposed to explore these variants in generalized anxiety disorder rather than panic disorder.

Indexed as

Panic DisorderAnxietyAnxiety DisordersDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA Methyltransferase 3BHumansPhenotypeDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDNMT3A protein, humanACQAnxiety disordersASIDNMT3ADNMT3BGeneralized anxiety disorderPanic disorderPSWQ

Identifiers

PMID32468273
OpenAlexW3028674744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.