Dually enhanced homogenous synthesis of molybdophosphate by hybridization chain reaction and enzyme nanotags for the electrochemical bioassay of carcinoembryonic antigen.

Xiaolei Cai, Fuhui Lv, Guosong Lai, Li Fu, Cheng-Te Lin, Aimin Yu

Abstract read

In one paragraph

Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiaolei CaiHubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, China.

Fuhui LvHubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, China.

Guosong LaiHubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, China. gslai@hbnu.edu.cn.ORCID 0000-0002-8083-1378

Li FuCollege of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, China.

Cheng-Te LinNingbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.

Aimin YuHubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, China. aiminyu@swin.edu.au.

Hubei Normal University · CNChinese Academy of Sciences · CNHangzhou Dianzi University · CN

Funding

Hubei Provincial Department of Education T201810National Natural Science Foundation of China 21475033

6 · The paper itself

Abstract

A magnetic bead (MB)-based sandwich biorecognition reactions is combined with a gold nanoprobe-induced homogenous synthesis of molybdophosphate to develop a novel bioassay method for the electrochemical detection of the tumor biomarker of carcinoembryonic antigen (CEA). The nanoprobe is prepared through the specific loading of numerous alkaline phosphatase (ALP)-functionalized gold nanoparticles (Au NPs) on a double-stranded DNA (dsDNA) produced by the CEA aptamer-triggered hybridization chain reaction (HCR). Both the large amounts of PO

Indexed as

Alkaline PhosphataseAntibodies, ImmobilizedAptamers, NucleotideBiomarkers, TumorCarcinoembryonic AntigenDNAElectrochemical TechniquesEnzymes, ImmobilizedGoldHumansImmunoassayImmunomagnetic SeparationLimit of DetectionMetal NanoparticlesMolybdenumNucleic Acid Amplification TechniquesAlkaline PhosphataseAntibodies, ImmobilizedAptamers, NucleotideBiomarkers, TumorCarcinoembryonic AntigenDNAEnzymes, ImmobilizedGoldMolybdenumphosphomolybdic acidPhosphoric AcidsBiosensorsElectroanalytical chemistryHybridization chain reactionMolybdophosphateProtein biomarker

Identifiers

PMID32468206

DOI10.1007/s00604-020-04342-3

OpenAlexW3031729751

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.