Evidence map›Paper›PMID 32468137›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Utilization of plant-derived Myricetin molecule coupled with ultrasound for the synthesis of gold nanoparticles against breast cancer.

Uma Priya Mohan, Bhaskaran Sriram, Theivendren Panneerselvam, Sankarganesh Devaraj, Davoodbasha MubarakAli, Pavadai Parasuraman, Ponnusamy Palanisamy, Adhvitha Premanand, Sankarganesh Arunachalam, Selvaraj Kunjiappan

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  8. Cytotoxic Potential of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2022
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  12. Aphrodisiac Performance of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2022
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Uma Priya MohanDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India.
Bhaskaran SriramSchool of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, 600048, India.
Theivendren PanneerselvamDepartment of Pharmaceutical Chemistry, Saraswathi College of Pharmacy, NH-24, Anwarpur, Pilkhuwa, Hapur, Uttar Pradesh, 245304, India.
Sankarganesh DevarajDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India.
Davoodbasha MubarakAliSchool of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, 600048, India.
Pavadai ParasuramanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, M S R Nagar, Bengaluru, Karnataka, 560054, India.
Ponnusamy PalanisamySchool of Mechanical Engineering, Vellore Institute of Technology, Vellore, Tamilnadu, 632014, India.
Adhvitha PremanandDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India.
Sankarganesh ArunachalamDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India. sankarganesh@gmail.com.
Selvaraj KunjiappanDepartment of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India. selvapharmabio@gmail.com.
Kalasalingam Academy of Research and Education · INB.S. Abdur Rahman Crescent Institute of Science & Technology · INIncheon National University · KRM S Ramaiah University of Applied Sciences · INVellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytochemical mediated synthesis of nanoparticles has gained great interest in the field of cancer therapeutics. We attempted a simple and stable synthesis of gold nanoparticles (AuNPs) with Myricetin (Myr) adopting ultrasound-assisted method. Further, we evaluated anticancer activity of the synthesized nanoparticles. The physico-chemical properties of biosynthesized Myr-AuNPs were characterized by UV-visible spectrophotometer, Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and particle size analysis. The study reports of Myr-AuNPs showed spherical-shaped particles with a size of < 50 nm. Stability of the particles was increased in various physiological media. Furthermore, the graph theoretical network analysis of Myr-AuNPs indicated that the probable binding with the mTOR is an effective target for breast cancer cells. In silico molecular docking study of Myr-AuNPs in human mTOR kinase was found to be strong binding. The IC

Indexed as

Breast NeoplasmsUltrasonic WavesAntineoplastic Agents, PhytogenicDose-Response Relationship, DrugFemaleFlavonoidsGoldHumansMCF-7 CellsMetal NanoparticlesAntineoplastic Agents, PhytogenicFlavonoidsGoldmyricetinApoptosisBreast cancerCytotoxicityGold nanoparticlesMCF-7 cellsMyricetin

Identifiers

PMID32468137
OpenAlexW3030092130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.