Evidence map›Paper›PMID 32468112›Full record

ArticleSurgery today2020

Conversion surgery for initially unresectable biliary malignancies: a multicenter retrospective cohort study.

Takehiro Noji, Minoru Nagayama, Koji Imai, Yasuyuki Kawamoto, Masaki Kuwatani, Masafumi Imamura, Keikuke Okamura, Yastoshi Kimura, Satoshi Hirano

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takehiro NojiGastroenterological Surgery II, Hokkaido University Faculty of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan. drnoji@med.hokudai.ac.jp.
Minoru NagayamaDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Koji ImaiDepartment of Surgery, Asahikawa Medical University, Asahikawa, Japan.
Yasuyuki KawamotoGastroenterology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Masaki KuwataniGastroenterology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Masafumi ImamuraDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Keikuke OkamuraGastroenterological Surgery II, Hokkaido University Faculty of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Yastoshi KimuraDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Satoshi HiranoGastroenterological Surgery II, Hokkaido University Faculty of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew studies have focused on conversion surgery for biliary malignancy; thus, it is not clear if this treatment modality can extend the survival of patients with unresectable biliary malignancy. We conducted a multicenter retrospective cohort study to evaluate the surgical outcomes of conversion surgery in this setting and analyze long-term survival.

methodsWe collected clinical data retrospectively on patients who underwent conversion surgery for biliary malignancy.

resultsTwenty-four patients met our inclusion criteria. Preoperative chemotherapy regimens or chemoradiation therapy regimens were administered based on the institutional criteria, and surgical procedures were chosen based on tumor location. Morbidity occurred in 16 patients (66.7%), and 1 patient died of liver failure after surgery. The overall 5-year survival rate following initial therapy was 43.2%, and the median survival time was 57.4 months. The corresponding values following surgery were 38.2% and 34.3 months, respectively. The 5-year survival rate of the 24 patients who received both chemotherapy and surgery was significantly better than that of 110 patients treated with chemotherapy only (p < 0.001).

conclusionConversion surgery for initially unresectable biliary malignancies may be feasible and achieve long-term survival for selected patients.

Indexed as

AdultAgedAged, 80 and overBiliary Tract NeoplasmsChemoradiotherapy, AdjuvantCohort StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedPreoperative CareRetrospective StudiesSurvival RateTreatment OutcomeBiliary malignancyConversion surgeryInitially unresectable tumor

Identifiers

PMID32468112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.