ArticleOncology reports2020
Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.
Article in Oncology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Hsa_circ_0002111 implicates KTC-1 cell motility and modulates migration and invasion via miR-432-5p/CDKN2B axis.Scientific reports · 2026Article
- Circular RNAs in cancer.MedComm · 2025Review
- METTL3-mediated m6A Modification of hsa_circ_0131922 Attenuates the Progression of Papillary Thyroid Cancer by Regulating the p53 Pathway.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Circ-METTL15 stimulates the aggressive behaviors of papillary thyroid cancer cells by coordinating the miR-200c-3p/XIAP axis.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Investigation ofGastroenterology and hepatology from bed to bench · 2024Article
- hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR-127-5p/CDH2.Journal of clinical laboratory analysis · 2022Article
- Function and Clinical Significance of Circular RNAs in Thyroid Cancer.Frontiers in molecular biosciences · 2022Review
- Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis.Journal of oncology · 2022Article
- Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research.Cancers · 2021Review
- CircRNA: A novel potential strategy to treat thyroid cancer (Review).International journal of molecular medicine · 2021Review
- Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.Oncology reports · 2021Article
- Exosomal Long Non-Coding RNA ANCR Mediates Drug Resistance in Osteosarcoma.Frontiers in oncology · 2021Article
- Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer.Frontiers in oncology · 2021Article
- Emerging Roles of Circular RNAs in Thyroid Cancer.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Circular RNAs (circRNAs) are a novel class of RNAs, with higher stability and tissue specificity, which may be of value as novel clinical markers. High‑throughput RNA sequencing was used to profile the expression of circRNAs in 5 pairs of cancer and normal tissues, and reverse transcription‑quantitative PCR (RT‑qPCR) analysis was employed to verify the results of the RNA sequencing in 45 cases of PTC. The dysregulated circRNA expression and clinicopathological characteristics were assessed and the potential roles of circRNAs in the cellular miRNA and mRNA network were predicted using bioinformatics analysis. The results demonstrated that, compared with normal tissues, a total of 53 circRNAs were dysregulated in tumour tissues, and 8 circRNAs were validated at the mRNA level (P<0.001 and P<0.01). Among those, the expression of chr5:161330882‑161336769‑ (P=0.015), chr9:22046750‑22097364+ (P=0.041) and chr8:18765448‑18804898‑ (P=0.036) were obviously associated with the BRAFV600E mutation, chr12:129699809‑129700698‑ was associated with capsular invasion (P=0.025) and chr5:38523418‑38530666‑ was associated with pT stage (P=0.037) and lymph node metastasis (P=0.002). Therefore, some dysregulated circRNAs were found to be associated with BRAFV600E mutation, capsular invasion, advanced pT stage and lymph node metastasis of PTC, indicating that circRNAs may be involved in tumourigenesis and cancer progression, and they may be putative biomarkers for the diagnosis and evaluation of progression of PTC.
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Registered trials
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