Evidence map›Paper›PMID 32467953›Full record

ArticleJournal of materials chemistry. B2020

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy.

Dali Sun, Li Yang, Christopher J Lyon, Tony Hu

Open access · greenAbstract read
In one paragraph

Article in Journal of materials chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dali SunDepartment of Electrical and Computer Engineering, North Dakota State University, 1411 Centennial Blvd., 101S Fargo, ND 58102, USA. dali.sun@ndsu.edu.
Li YangDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Christopher J LyonDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Tony HuDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0001-7255-5409
Tulane University · USDakota State University · US

Funding

Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5M
Quantification of Circulating Antigens for Pediatric TB Diagnosis andTreatment MonitoringR01AI122932 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HU, TONY Y. · 2016 to 2019
$1.8M
Real-time Detection of Active TB in HIV Exposed Children on CustomizedNanotrapR01AI113725 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LABAER, JOSHUA · 2015 to 2018
$1.6M
Multiplexed quantification of circulating peptidomic signatures for EBOLA early diagnosisR21AI126361 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LABAER, JOSHUA · 2017 to 2018
$373k
Mobile based Nanoplasmonic Quantification of Mtb-derived Exosomes in Serum for Pediatric TB diagnosisR21EB026347 · NIBIB · TULANE UNIVERSITY OF LOUISIANA · PI LYON, CHRISTOPHER J · 2019 to 2020
$367k
NIAID NIH HHS R01 AI113725NIAID NIH HHS R01 AI122932NIAID NIH HHS R21 AI126361NIBIB NIH HHS R21 EB026347NICHD NIH HHS R01 HD090927
6 · The paper itself

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

Indexed as

MicroscopyGoldMetal NanoparticlesParticle SizeSurface PropertiesGold

Identifiers

PMID32467953
PMCPMC7386073
OpenAlexW3027045935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.