Evidence map›Paper›PMID 32467881›Full record

ArticleACS applied bio materials2020

Biocompatible PEGDA Resin for 3D Printing.

Chandler Warr, Jonard Corpuz Valdoz, Bryce P Bickham, Connor J Knight, Nicholas A Franks, Nicholas Chartrand, Pam M Van Ry, Kenneth A Christensen, Gregory P Nordin, Alonzo D Cook

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Microfluidic Nanoparticle Separation for Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chandler WarrChemical Engineering Department, Brigham Young University, Provo, Utah, USA 84602.
Jonard Corpuz ValdozChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Bryce P BickhamElectrical and Computer Engineering Department, Brigham Young University, Provo, Utah, USA 84602.
Connor J KnightChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Nicholas A FranksChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Nicholas ChartrandChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Pam M Van RyChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Kenneth A ChristensenChemistry and Biochemistry Department, Brigham Young University, Provo, Utah, USA 84602.
Gregory P NordinElectrical and Computer Engineering Department, Brigham Young University, Provo, Utah, USA 84602.
Alonzo D CookChemical Engineering Department, Brigham Young University, Provo, Utah, USA 84602.
Brigham Young University · US

Funding

High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
NIGMS NIH HHS R15 GM123405
6 · The paper itself

Abstract

We report a non-cytotoxic resin compatible with and designed for use in custom high-resolution 3D printers that follow the design approach described in Gong et al., Lab Chip 17, 2899 (2017). The non-cytotoxic resin is based on a poly(ethylene glycol) diacrylate (PEGDA) monomer with avobenzone as the UV absorber instead of 2-nitrophenyl phenyl sulfide (NPS). Both NPS-PEGDA and avobenzone-PEGDA (A-PEGDA) resins were evaluated for cytotoxicity and cell adhesion. We show that NPS-PEGDA can be made effectively non-cytotoxic with a post-print 12-hour ethanol wash, and that A-PEGDA, as-printed, is effectively non-cytotoxic. 3D prints made with either resin do not support strong cell adhesion in their as-printed state; however, cell adhesion increases dramatically with a short plasma treatment. Using A-PEGDA, we demonstrate spheroid formation in ultra-low adhesion 3D printed wells, and cell migration from spheroids on plasma-treated adherent surfaces. Given that A-PEGDA can be 3D printed with high resolution, it has significant promise for a wide variety of cell-based applications using 3D printed microfluidic structures.

Indexed as

3D printingbiocompatibilitycytotoxicitymicrofluidicsresinspheroid

Identifiers

PMID32467881
PMCPMC7255423
OpenAlexW3007771729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.