ArticleCurrent opinion in physiology2020
Sleep and ageing: from human studies to rodent models.
Article in Current opinion in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Review
- The myth of the metabolic baseline: sleep-wake cycles undermine a foundational assumption in organismal biology.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus.Neurobiology of sleep and circadian rhythms · 2026Article
- Links Between Autophagy and Healthy Aging.Journal of molecular biology · 2026Review
- Article
- Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV.Frontiers in neuroscience · 2025Article
- Sleep deprivation affects memory function, depression and anxiety-like behaviours in rats and mice: a systematic review and meta-analysis.Brain communications · 2025Review
- Effects of Age and MPTP-Induced Parkinson's Disease on the Expression of Genes Associated with the Regulation of the Sleep-Wake Cycle in Mice.International journal of molecular sciences · 2024Article
- Neuroimmune Mechanisms of Opioid Use Disorder and Recovery: Translatability to Human Studies, and Future Research Directions.Neuroscience · 2023Review
- The impact of insomnia on frailty and the hallmarks of aging.Aging clinical and experimental research · 2023Review
- Article
- An aqueous extract of the brown algaAging · 2022Article
- Non-invasive sleep EEG measurement in hand raised wolves.Scientific reports · 2022Article
- Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases.JAMA neurology · 2022Article
- Microglial repopulation alleviates age-related decline of stable wakefulness in mice.Frontiers in aging neuroscience · 2022Article
- Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study.JMIR research protocols · 2021Article
- Sleeping at the switch.eLife · 2021Article
- Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth.Sleep medicine · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Sleep duration and lifespan vary greatly across Animalia. Human studies have demonstrated that ageing reduces the ability to obtain deep restorative sleep, and this may play a causative role in the development of age-related neurodegenerative disorders. Animal models are widely used in sleep and ageing studies. Importantly, in contrast to human studies, evidence from laboratory rodents suggests that sleep duration is increased with ageing, while evidence for reduced sleep intensity and consolidation is inconsistent. Here we discuss two possible explanations for these species differences. First, methodological differences between studies in humans and laboratory rodents may prevent straightforward comparison. Second, the role of ecological factors, which have a profound influence on both ageing and sleep, must be taken into account. We propose that the dynamics of sleep across the lifespan reflect both age-dependent changes in the neurobiological substrates of sleep as well as the capacity to adapt to the environment.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.