Evidence map›Paper›PMID 32467729›Full record

ArticleBiotechnology for biofuels2020

Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom

Richard P Haslam, Mary L Hamilton, Chloe K Economou, Richard Smith, Kirsty L Hassall, Johnathan A Napier, Olga Sayanova

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
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  5. Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  6. Genetic engineering in diatoms: advances and prospects.The Plant journal : for cell and molecular biology · 2025
    Review
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  13. Comparison of twoFrontiers in plant science · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Richard P Haslam *1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Mary L Hamilton *1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Chloe K Economou1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Richard Smith1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Kirsty L Hassall5Department of Computational and Analytical Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Johnathan A Napier1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.
Olga Sayanova1Department of Plant Sciences, Rothamsted Research, Harpenden, Herts AL5 2JQ UK.ORCID 0000-0002-8484-2322
Rothamsted Research · GBQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOleaginous microalgae represent a valuable resource for the production of high-value molecules. Considering the importance of omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) for human health and nutrition the yields of high-value eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) require significant improvement to meet demand; however, the current cost of production remains high. A promising approach is to metabolically engineer strains with enhanced levels of triacylglycerols (TAGs) enriched in EPA and DHA.

resultsRecently, we have engineered the marine diatom

conclusionThis study provides further insight into lipid metabolism in

Indexed as

Acyl-CoA:diacylglycerol acyltransferase (DGAT)Docosahexaenoic acidEicosapentaenoic acidOmega-3 fatty acidsPhaeodactylum tricornutumTriacylgycerol

Identifiers

PMID32467729
PMCPMC7227059
OpenAlexW3028715706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.