Evidence map›Paper›PMID 32467717›Full record

ArticleJournal of occupational medicine and toxicology (London, England)2020

The riddle of shiftwork and disturbed chronobiology: a case study of landmark smoking data demonstrates fallacies of not considering the ubiquity of an exposure.

Thomas C Erren, Philip Lewis, Peter Morfeld

Abstract read
In one paragraph

Article in Journal of occupational medicine and toxicology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas C ErrenInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, 50937 Cologne, Germany.
Philip LewisInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, 50937 Cologne, Germany.ORCID https://orcid.org/0000-0002-5881-6032
Peter MorfeldInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, 50937 Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFailing to integrate all sources of a ubiquitous hazard candidate may explain inconsistent and/or null, and overall misleading, results in epidemiological studies such as those related to shift-work.

methodsWe explore this rationale on the assumption that Doll and Hill had confined their 1950 landmark study to smoking at workplaces alone. We assess how non-differential, or how differential, underestimation of exposure could have biased computed risks.

resultsSystematically unappreciated exposures at play could have led to substantial information bias. Beyond affecting the magnitude of risks, not even the direction of risk distortion would have been predictable.

conclusionsDisturbed chronobiology research should consider cumulative doses from all walks of life. This is a

Indexed as

BiasCancerChronobiologyCircadianExposure assessmentInformation biasNight workShiftwork

Identifiers

PMID32467717
PMCPMC7236101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.