Evidence map›Paper›PMID 32467331›Full record

ArticleScience (New York, N.Y.)2020

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity.

Alexander J Meeske, Ning Jia, Alice K Cassel, Albina Kozlova, Jingqiu Liao, Martin Wiedmann, Dinshaw J Patel, Luciano A Marraffini

Open access · bronzeAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 118 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Article
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  8. [Research on Bacteriophage Resistance: Coevolutionary Arms Race Between Bacteria and Phages Drives Novel Antibacterial Therapies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  9. Genomic characterization of a pathogenicFrontiers in microbiology · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alexander J Meeske *Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-3878-531X
Ning Jia *Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-0672-454X
Alice K CasselLaboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0002-2077-7402
Albina KozlovaLaboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-4249-0282
Jingqiu LiaoDepartment of Food Science, Cornell University, Ithaca, NY 14583, USA.ORCID 0000-0002-2579-8157
Martin WiedmannDepartment of Food Science, Cornell University, Ithaca, NY 14583, USA.ORCID 0000-0002-4168-5662
Dinshaw J PatelStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. marraffini@rockefeller.edu pateld@mskcc.org.ORCID 0000-0002-9779-7778
Luciano A MarraffiniLaboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA. marraffini@rockefeller.edu pateld@mskcc.org.ORCID 0000-0002-9163-0969
Rockefeller University · USCornell University · USMemorial Sloan Kettering Cancer Center · USHoward Hughes Medical Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Generation of immunological memory by CRISPR-Cas systemsDP1GM128184 · NIGMS · ROCKEFELLER UNIVERSITY · PI MARRAFFINI, LUCIANO A · 2017 to 2021
$5.9M
'Class I and III Multi-subunit CRISPR-Cas Surveillance Complexes: Recognition, Cleavage, Autoimmunity and Inhibition’R01GM129430 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PATEL, DINSHAW J · 2019 to 2022
$1.4M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748NIGMS NIH HHS DP1 GM128184NIGMS NIH HHS R01 GM129430
6 · The paper itself

Abstract

The CRISPR RNA (crRNA)-guided nuclease Cas13 recognizes complementary viral transcripts to trigger the degradation of both host and viral RNA during the type VI CRISPR-Cas antiviral response. However, how viruses can counteract this immunity is not known. We describe a listeriaphage (ϕLS46) encoding an anti-CRISPR protein (AcrVIA1) that inactivates the type VI-A CRISPR system of

Indexed as

CRISPR-Cas SystemsBacteriophagesClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated ProteinsDNA CleavageEndonucleasesListeriaRNA, Guide, CRISPR-Cas SystemsRNA StabilityRNA, ViralViral ProteinsCRISPR-Associated ProteinsEndonucleasesRNA, Guide, CRISPR-Cas SystemsRNA, ViralViral Proteins

Identifiers

PMID32467331
PMCPMC7975689
OpenAlexW3031702315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.