Evidence map›Paper›PMID 32467324›Full record

ArticleCancer immunology research2020

Inflammation-Induced Abnormal Expression of Self-molecules on Epithelial Cells: Targets for Tumor Immunoprevention.

Camille Jacqueline, Amanda Lee, Nolan Frey, Jonathan S Minden, Olivera J Finn

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Tumor microenvironment antigens.Seminars in immunopathology · 2023
    Review
  7. Article
  8. Article
  9. Beneficial autoimmunity improves cancer prognosis.Nature reviews. Clinical oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Camille JacquelineDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Amanda LeeDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.ORCID 0000-0001-8902-7899
Nolan FreyDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.ORCID 0000-0002-1889-1724
Jonathan S MindenDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.ORCID 0000-0003-3175-393X
Olivera J FinnDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. ojfinn@pitt.edu.
Carnegie Mellon University · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Immunoprevention and immunosurveillance of human non-viral cancersR35CA210039 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINN, OLIVERA J · 2016 to 2022
$6.0M
NCI NIH HHS P30 CA047904NCI NIH HHS R35 CA210039
6 · The paper itself

Abstract

Tumor-associated antigens (TAA) are self-molecules abnormally expressed on tumor cells, which elicit humoral and cellular immunity and are targets of immunosurveillance. Immunity to TAAs is found in some healthy individuals with no history of cancer and correlates positively with a history of acute inflammatory and infectious events and cancer risk reduction. This suggests a potential role in cancer immunosurveillance for the immune memory elicited against disease-associated antigens (DAA) expressed on infected and inflamed tissues that are later recognized on tumors as TAAs. To understand probable sources for DAA generation, we investigated

Indexed as

Antigens, NeoplasmAutoantigensCancer VaccinesCells, CulturedEpithelial CellsHealthy VolunteersHumansInflammationLeukocytes, MononuclearMacrophagesMonitoring, ImmunologicNeoplasmsProteomicsAntigens, NeoplasmAutoantigensCancer Vaccines

Identifiers

PMID32467324
PMCPMC7415557
OpenAlexW3031160611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.